Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity.
Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity.
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DOI：
10.1084/jem.20071734
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发表时间：
2008-03-17
期刊：
影响因子：
--
通讯作者：
Rescigno M
中科院分区：
文献类型：
--
作者：
Rotta G;Matteoli G;Mazzini E;Nuciforo P;Colombo MP;Rescigno M
基质细胞蛋白在细菌遏制和诱导病原体特异性适应性免疫应答中的作用尚不清楚。我们研究了基质细胞蛋白分泌的蛋白质，酸性和富含半胱氨酸（骨结合素/骨连接素）在局部注射鼠伤寒沙门氏菌的传播和随后的免疫反应中的功能。我们表明，组织急性炎症反应与肉芽肿样（GL）功能的发展，并为控制细菌扩散到引流淋巴结（DLN）所需的。然而，SPARC相关GL也抑制树突状细胞（DC）迁移到DLN，并限制适应性免疫反应的发展，从而增加对病原体的易感性。在SPARC缺陷小鼠中，DC迁移和抗原特异性反应都恢复了对细菌的抵抗，导致保护性抗S。鼠伤寒免疫这凸显了基质细胞蛋白在细菌感染中的新功能，并表明细菌的初始遏制可能存在缺陷。
The role of matricellular proteins in bacterial containment and in the induction of pathogen-specific adaptive immune responses is unknown. We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response. We show that SPARC was required for the development of organized acute inflammatory reactions with granuloma-like (GL) features and for the control of bacterial spreading to draining lymph nodes (DLNs). However, SPARC-related GL also inhibited dendritic cell (DC) migration to the DLNs and limited the development of adaptive immune response, thus conferring increased susceptibility to the pathogen. In SPARC-deficient mice, both DC migration and antigen-specific responses were restored against bacteria, leading to protective anti–S. typhimurium immunity. This highlights a new function of matricellular proteins in bacterial infection and suggests that initial containment of bacteria can have drawbacks.
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影响因子：
3.3
作者：
Kaarteenaho-Wiik, Riitta;Sademies, Outi;Somi, Ylermi
通讯作者：
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影响因子：
1.2
作者：
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DOI：
10.1073/pnas.120163297
发表时间：
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影响因子：
11.1
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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