Lung nodule volumetry: segmentation algorithms within the same software package cannot be used interchangeably.

Lung nodule volumetry: segmentation algorithms within the same software package cannot be used interchangeably.
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DOI:
10.1007/s00330-010-1749-z
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发表时间:
2010-08
期刊:
影响因子:
5.9
通讯作者:
Pedersen JH
Pedersen JH
中科院分区:
医学2区
文献类型:
--
作者:
Ashraf H;de Hoop B;Shaker SB;Dirksen A;Bach KS;Hansen H;Prokop M;Pedersen JH

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We examined the reproducibility of lung nodule volumetry software that offers three different volumetry algorithms. In a lung cancer screening trial, 188 baseline nodules >5 mm were identified. Including follow-ups, these nodules formed a study-set of 545 nodules. Nodules were independently double read by two readers using commercially available volumetry software. The software offers readers three different analysing algorithms. We compared the inter-observer variability of nodule volumetry when the readers used the same and different algorithms. Both readers were able to correctly segment and measure 72% of nodules. In 80% of these cases, the readers chose the same algorithm. When readers used the same algorithm, exactly the same volume was measured in 50% of readings and a difference of >25% was observed in 4%. When the readers used different algorithms, 83% of measurements showed a difference of >25%. Modern volumetric software failed to correctly segment a high number of screen detected nodules. While choosing a different algorithm can yield better segmentation of a lung nodule, reproducibility of volumetric measurements deteriorates substantially when different algorithms were used. It is crucial even in the same software package to choose identical parameters for follow-up.
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