Characterization of marine aerosol for assessment of human exposure to brevetoxins.
Characterization of marine aerosol for assessment of human exposure to brevetoxins.
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DOI：
10.1289/ehp.7496
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发表时间：
2005-05
影响因子：
10.4
通讯作者：
Baden DG
中科院分区：
文献类型：
--
作者：
Cheng YS;Zhou Y;Irvin CM;Pierce RH;Naar J;Backer LC;Fleming LE;Kirkpatrick B;Baden DG
墨西哥湾的赤潮通常是由杀鱼的甲藻Karenia brevis形成的，它产生九种强效聚醚短毒素（PbTxs）。Brevetoxins可以在风力驱动的白浪中从水转移到空气中。吸入含有短尾丝虫毒素的海洋气溶胶可引起呼吸道症状。我们描述了在职业暴露于佛罗里达赤潮气溶胶的浓度，毒素档案和粒度分布的流行病学研究过程中的气溶胶的详细表征。这一信息对于了解其来源、评估人的接触情况和估计吸入气溶胶的剂量至关重要。环境取样证实，在赤潮暴露期间（2001年9月），水和空气中存在短尾藻毒素，而在未暴露期间（2002年5月），水和空气中没有明显的毒素水平。在二○ ○一年一次红潮爆发期间所收集的海水样本显示，钾的浓度属中等至偏高。brevis细胞和PbTxs。2001年9月7日至11日期间，水样中的每日平均PbTx浓度为8至28微克/升;空气样品中的每日平均PbTx浓度为1.3至27纳克/立方米。海滩上的气溶胶日浓度与水中PbTx浓度、风速和风向有关。个人样本证实人类曾接触红潮气溶胶。粒度分布显示平均空气动力学直径在6-12 μm的尺寸范围内，沉积物主要在上气道中。沉积模式与健康救生员在暴露期间观察到的上呼吸道症状增加相关。
Red tides in the Gulf of Mexico are commonly formed by the fish-killing dinoflagellate Karenia brevis, which produces nine potent polyether brevetoxins (PbTxs). Brevetoxins can be transferred from water to air in wind-powered white-capped waves. Inhalation exposure to marine aerosol containing brevetoxins causes respiratory symptoms. We describe detailed characterization of aerosols during an epidemiologic study of occupational exposure to Florida red tide aerosol in terms of its concentration, toxin profile, and particle size distribution. This information is essential in understanding its source, assessing exposure to people, and estimating dose of inhaled aerosols. Environmental sampling confirmed the presence of brevetoxins in water and air during a red tide exposure period (September 2001) and lack of significant toxin levels in the water and air during an unexposed period May 2002). Water samples collected during a red tide bloom in 2001 showed moderate-to-high concentrations of K. brevis cells and PbTxs. The daily mean PbTx concentration in water samples ranged from 8 to 28 μg/L from 7 to 11 September 2001; the daily mean PbTx concentration in air samples ranged from 1.3 to 27 ng/m3. The daily aerosol concentration on the beach can be related to PbTx concentration in water, wind speed, and wind direction. Personal samples confirmed human exposure to red tide aerosols. The particle size distribution showed a mean aerodynamic diameter in the size range of 6–12 μm, with deposits mainly in the upper airways. The deposition pattern correlated with the observed increase of upper airway symptoms in healthy lifeguards during the exposure periods.
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影响因子：
6.6
作者：
Backer, LC;Fleming, LE;Baden, DG
通讯作者：
Baden, DG
DOI：
10.1007/s00128-002-0170-y
发表时间：
2003-01-01
影响因子：
2.7
作者：
Pierce, RH;Henry, MS;Zhou, Y
通讯作者：
Zhou, Y
影响因子：
2.8
作者：
TRAINER, VL;BADEN, DG
通讯作者：
BADEN, DG
影响因子：
14.2
作者：
ASAI, S;KRZANOWSKI, JJ;SZENTIVANYI, A
通讯作者：
SZENTIVANYI, A
一种竞争性ELISA，可检测海水，贝类和哺乳动物体液中的Karenia Brevis（以前是Bredinium Breve）的Brevetoxins。
影响因子：
10.4
作者：
Naar J;Bourdelais A;Tomas C;Kubanek J;Whitney PL;Flewelling L;Steidinger K;Lancaster J;Baden DG
通讯作者：
Baden DG