Applications of Metals for Bone Regeneration.
Applications of Metals for Bone Regeneration.
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DOI：
10.3390/ijms19030826
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发表时间：
2018-03-12
影响因子：
5.6
通讯作者：
Barbeck M
中科院分区：
文献类型：
--
作者：
Glenske K;Donkiewicz P;Köwitsch A;Milosevic-Oljaca N;Rider P;Rofall S;Franke J;Jung O;Smeets R;Schnettler R;Wenisch S;Barbeck M
骨组织的再生是牙科医学中大多数治疗的主要目的。对于骨再生，基于天然（同种异体和异种移植物）和合成来源（异体材料）的磷酸钙（CaP）基替代材料用于指导再生过程。最佳的骨替代物必须作为骨长入缺损的基质，以及在完全再生所需的时间范围内再吸收，直至完全恢复的条件。在这种情况下，基于CaP的替代材料的作用模式已被频繁研究，其中已表明，由于材料的不同物理化学性质，此类材料强烈影响再生过程，例如成骨细胞生长或分化以及骨吸收。然而，到目前为止，尚未发现新骨组织形成和材料降解之间所需比率所需的材料特性。已经测试了添加不同的物质如胶原或生长因子以及不同的细胞类型，但不允许充分或迅速应用。此外，在骨再生领域中，金属或金属离子被不同地用作不同材料的基础或补充。此外，已经表明，不同的金属离子是骨组织的组成部分，在生理细胞环境以及骨愈合过程中发挥功能作用。本综述重点介绍了常用的金属作为骨再生材料的组成部分，旨在概述目前现有的知识，在骨再生领域的金属的影响。
The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well as resorb in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated, where it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between new bone tissue formation and material degradation has not been found, until now. The addition of different substances such as collagen or growth factors and also of different cell types has already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are used differently as a basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue, playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.
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DOI：
10.1016/j.nano.2016.01.020
发表时间：
2016-07-01
影响因子：
5.4
作者：
Ahmadzadeh, Elham;Talebnia, Farid;Mostaghaci, Babak
通讯作者：
Mostaghaci, Babak
DOI：
10.1084/jem.190.12.1741
发表时间：
1999-12-20
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
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影响因子：
4.2
作者：
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Kim, Mi-Hyun
影响因子：
10.8
作者：
Bae, Soon Eon;Choi, Jiyeon;Han, Dong Keun
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影响因子：
6.2
作者：
Alexander, Kylie A.;Chang, Ming K.;Pettit, Allison R.
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Pettit, Allison R.