The Anopheles gambiae adult midgut peritrophic matrix proteome.
The Anopheles gambiae adult midgut peritrophic matrix proteome.
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DOI：
10.1016/j.ibmb.2008.10.010
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发表时间：
2009-02
影响因子：
3.8
通讯作者：
Jacobs-Lorena, M.
中科院分区：
文献类型：
--
作者：
Dinglasan, R. R.;Devenport, M.;Florens, L.;Johnson, J. R.;McHugh, C. A.;Donnelly-Doman, M.;Carucci, D. J.;Yates, J. R., III;Jacobs-Lorena, M.
疟疾是一种毁灭性的疾病。要发生传播，疟疾的病原体疟原虫必须在其蚊子载体中完成一个复杂的发育周期。因此，蚊子是疾病控制的潜在目标。疟原虫动卵细胞在蚊子中肠内发育，必须首先穿过中肠的围食基质（PM），这是一种完全包围血粉的厚细胞外鞘。PM对寄生虫入侵中肠构成部分天然屏障，并且推测对PM的修饰可能导致对感染的完全屏障。然而，这样的战略需要对项目管理的结构进行彻底的描述。在这里，我们描述的第一次，完整的PM蛋白质组的主要疟疾媒介，冈比亚按蚊。共鉴定出209种蛋白质。其中有9个新的几丁质结合围食基质蛋白，扩大名单从3至12 peritrophins。最后，我们提供了一个模型，在这项研究中确定的蛋白质之间的假定相互作用。
Malaria is a devastating disease. For transmission to occur, Plasmodium, the causative agent of malaria, must complete a complex developmental cycle in its mosquito vector. Thus, the mosquito is a potential target for disease control. Plasmodium ookinetes, which develop within the mosquito midgut, must first cross the midgut's peritrophic matrix (PM), a thick extracellular sheath that completely surrounds the blood meal. The PM poses a partial, natural barrier against parasite invasion of the midgut and it is speculated that modifications to the PM may lead to a complete barrier to infection. However, such strategies require a thorough characterization of the structure of the PM. Here, we describe for the first time, the complete PM proteome of the main malaria vector, Anopheles gambiae. Altogether, 209 proteins were identified by mass spectrometry. Among them were nine new chitin-binding peritrophic matrix proteins, expanding the list from three to twelve peritrophins. Lastly, we provide a model for the putative interactions among the proteins identified in this study.
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影响因子：
2.6
作者：
Moskalyk, LA;Oo, MM;JacobsLorena, M
通讯作者：
JacobsLorena, M
影响因子：
3.6
作者：
Devenport, M;Fujioka, H;Jacobs-Lorena, M
通讯作者：
Jacobs-Lorena, M
影响因子：
3.1
作者：
Langer, RC;Li, FW;Vinetz, JM
通讯作者：
Vinetz, JM
影响因子：
3.8
作者：
Lemos, FJA;Cornel, AJ;JacobsLorena, M
通讯作者：
JacobsLorena, M
影响因子：
11.4
作者：
MULLER, HM;CRAMPTON, JM;CRISANTI, A
通讯作者：
CRISANTI, A