Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health.
Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health.
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乳酸菌作为生物标志物和制剂，可以促进阴道健康的各个方面。
DOI：
10.3389/fphys.2015.00081
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发表时间：
2015
影响因子：
4
通讯作者：
Lebeer S
中科院分区：
文献类型：
--
作者：
Petrova MI;Lievens E;Malik S;Imholz N;Lebeer S
人体被大量的微生物定植，统称为人体微生物群。女性生殖道是主要的微生物群体位之一，在大约70%的女性中，通常以乳杆菌属为主。在任何女性身上观察到的核糖型中，每一个物种都可以构成大约99%。最常见的分离种是crispatus乳杆菌、Lactobacillus gasseri、Lactobacillus jensen和Lactobacillus iners。阴道乳杆菌位于细菌和病毒病原体的入境口岸，由于其主要代谢产物在宫颈阴道液中分泌，对细菌和病毒感染具有重要的抑制作用，因此可以对病原体的入侵形成屏障。因此，以乳酸杆菌为主的微生物群似乎是健康阴道生态系统的良好生物标志物。在月经、性活动、怀孕和各种感染等过程中，这种平衡可能会迅速改变。异常阴道微生物群的特征是微生物种类的多样性增加，导致一种称为细菌性阴道病的疾病。通过使用Nugent评分或Amsel标准，或在分子水平上通过调查乳酸杆菌种类的数量和类型，可以从对宫颈阴道液的分析中收集阴道微生物群的信息。然而，当将其转化为临床环境时，应该注意的是，乳酸菌主导的微生物群的缺乏似乎并不直接意味着疾病或生态失调。尽管如此，阴道乳酸杆菌物种的有益作用被广泛记录，这表明乳酸杆菌的组成和活性数据作为阴道健康的生物标志物具有潜力。这些生物标志物的证实和进一步验证将允许设计更好的靶向益生菌策略。
The human body is colonized by a vast number of microorganisms collectively referred to as the human microbiota. One of the main microbiota body sites is the female genital tract, commonly dominated by Lactobacillus spp., in approximately 70% of women. Each individual species can constitute approximately 99% of the ribotypes observed in any individual woman. The most frequently isolated species are Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus jensenii and Lactobacillus iners. Residing at the port of entry of bacterial and viral pathogens, the vaginal Lactobacillus species can create a barrier against pathogen invasion since mainly products of their metabolism secreted in the cervicovaginal fluid can play an important role in the inhibition of bacterial and viral infections. Therefore, a Lactobacillus-dominated microbiota appears to be a good biomarker for a healthy vaginal ecosystem. This balance can be rapidly altered during processes such as menstruation, sexual activity, pregnancy and various infections. An abnormal vaginal microbiota is characterized by an increased diversity of microbial species, leading to a condition known as bacterial vaginosis. Information on the vaginal microbiota can be gathered from the analysis of cervicovaginal fluid, by using the Nugent scoring or the Amsel's criteria, or at the molecular level by investigating the number and type of Lactobacillus species. However, when translating this to the clinical setting, it should be noted that the absence of a Lactobacillus-dominated microbiota does not appear to directly imply a diseased condition or dysbiosis. Nevertheless, the widely documented beneficial role of vaginal Lactobacillus species demonstrates the potential of data on the composition and activity of lactobacilli as biomarkers for vaginal health. The substantiation and further validation of such biomarkers will allow the design of better targeted probiotic strategies.
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影响因子：
3.7
作者：
Bisanz JE;Seney S;McMillan A;Vongsa R;Koenig D;Wong L;Dvoracek B;Gloor GB;Sumarah M;Ford B;Herman D;Burton JP;Reid G
通讯作者：
Reid G
DOI：
10.1086/657320
发表时间：
2010-12-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brotman RM;Klebanoff MA;Nansel TR;Yu KF;Andrews WW;Zhang J;Schwebke JR
通讯作者：
Schwebke JR
影响因子：
11.8
作者：
Cherpes, TL;Melan, MA;Hillier, SL
通讯作者：
Hillier, SL
影响因子：
3.7
作者：
Anukam, Kingsley C.;Macklaim, Jean M.;Siezen, Roland J.
通讯作者：
Siezen, Roland J.
影响因子：
2.9
作者：
Anukam, Kingsley C.;Osazuwa, Emanual O.;Reid, Gregor
通讯作者：
Reid, Gregor