Rescue effects: irradiated cells helped by unirradiated bystander cells.
Rescue effects: irradiated cells helped by unirradiated bystander cells.
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DOI：
10.3390/ijms16022591
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发表时间：
2015-01-23
影响因子：
5.6
通讯作者：
Yu KN
中科院分区：
文献类型：
--
作者：
Lam RK;Fung YK;Han W;Yu KN
救援效应描述了受辐射的细胞或生物体从旁观者发送的未受辐射的细胞或生物体发出的反馈信号中受益的现象。好处的一个例子是减轻受辐射细胞中辐射诱导的DNA损伤。救援效果可能会影响放射免疫治疗(RIT)(实际上是所有放射治疗)的疗效。本文对救援效果的发现和后续的验证研究进行了综述。综述了迄今为止所研究的救援效果的机制和化学信使。文中还描述了辐照后的斑马鱼胚胎和未辐照的斑马鱼胚胎在体内共用相同介质时的救援效果。在讨论部分，对涉及核因子κB(NF-κB)途径激活的救援效应的机制进行了仔细的审查。这一机制可以解释辐射促进细胞存活和DNA损伤的正确修复、依赖环磷酸腺苷(CAMP)和调节细胞内活性氧自由基(ROS)水平。建议开发NF-κB通路以提高RIT的有效性。最后，还讨论了以斑马鱼胚胎为模型研究RIT治疗实体瘤疗效的可能性。
The rescue effect describes the phenomenon where irradiated cells or organisms derive benefits from the feedback signals sent from the bystander unirradiated cells or organisms. An example of the benefit is the mitigation of radiation-induced DNA damages in the irradiated cells. The rescue effect can compromise the efficacy of radioimmunotherapy (RIT) (and actually all radiotherapy). In this paper, the discovery and subsequent confirmation studies on the rescue effect were reviewed. The mechanisms and the chemical messengers responsible for the rescue effect studied to date were summarized. The rescue effect between irradiated and bystander unirradiated zebrafish embryos in vivo sharing the same medium was also described. In the discussion section, the mechanism proposed for the rescue effect involving activation of the nuclear factor κB (NF-κB) pathway was scrutinized. This mechanism could explain the promotion of cellular survival and correct repair of DNA damage, dependence on cyclic adenosine monophosphate (cAMP) and modulation of intracellular reactive oxygen species (ROS) level in irradiated cells. Exploitation of the NF-κB pathway to improve the effectiveness of RIT was proposed. Finally, the possibility of using zebrafish embryos as the model to study the efficacy of RIT in treating solid tumors was also discussed.
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影响因子：
10.5
作者：
Hochedlinger, K;Blelloch, R;Jaenisch, R
通讯作者：
Jaenisch, R
影响因子：
1
作者：
Facoetti, A.;Ballarini, F.;Zilio, C.
通讯作者：
Zilio, C.
影响因子：
1.6
作者：
Choi, V. W. Y.;Wong, M. Y. P.;Yu, K. N.
通讯作者：
Yu, K. N.
DOI：
10.1016/j.mrfmmm.2005.12.001
发表时间：
2006-05-11
影响因子：
2.3
作者：
Little, John B.
通讯作者：
Little, John B.
影响因子：
4.6
作者：
Le, Xiuning;Pugach, Emily K.;Zon, Leonard I.
通讯作者：
Zon, Leonard I.