Insulinemic and Inflammatory Dietary Patterns Show Enhanced Predictive Potential for Type 2 Diabetes Risk in Postmenopausal Women.
Insulinemic and Inflammatory Dietary Patterns Show Enhanced Predictive Potential for Type 2 Diabetes Risk in Postmenopausal Women.
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DOI：
10.2337/dc20-2216
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发表时间：
2021-03
期刊：
影响因子：
16.2
通讯作者：
Tabung FK
中科院分区：
文献类型：
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作者：
Jin Q;Shi N;Aroke D;Lee DH;Joseph JJ;Donneyong M;Conwell DL;Hart PA;Zhang X;Clinton SK;Cruz-Monserrate Z;Brasky TM;Jackson R;Tinker LF;Liu S;Phillips LS;Shadyab AH;Nassir R;Bao W;Tabung FK
高胰岛素血症经验饮食指数（EDIH）和经验饮食炎症模式（EDIP）评分评估习惯性饮食模式的胰岛素血症和炎症潜力，无论常量营养素含量如何，并分别基于血浆胰岛素反应或炎症生物标志物。血糖指数（GI）和血糖负荷（GL）基于饮食碳水化合物含量评估餐后血糖潜力。我们检验了促进高胰岛素血症、慢性炎症或高血糖的饮食模式可能影响2型糖尿病风险的假设。我们从基线（1993-1998）食物频率问卷中计算了73，495名绝经后妇女的饮食评分，随访至2019年3月。我们使用多变量校正的考克斯回归来估计2型糖尿病风险的风险比（HR）和95% CI。我们还估计了2型糖尿病的多变量校正绝对风险。在平均13.3年的随访中，诊断出11，009例2型糖尿病。高胰岛素血症或促炎饮食模式的参与者患2型糖尿病的风险更高;比较最高和最低饮食指数五分位数的HR（95%CI）分别为EDIH 1.49（1.32-1.68; Ptrend < 0.0001）和EDIP 1.45（1.29-1.63; Ptrend < 0.0001）。相同比较的绝对超额发生率为每10万人年220例（EDIH）和271例（EDIP）。GI和GL与2型糖尿病风险无关：GI 0.99（0.88-1.12; P趋势= 0.46）和GL 1.01（0.89-1.16; P趋势= 0.30）。我们在这个绝经后妇女的多样化队列中的研究结果表明，降低饮食的胰岛素和炎症潜力可能比专注于血糖食物更有效地预防2型糖尿病。
The empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores assess the insulinemic and inflammatory potentials of habitual dietary patterns, irrespective of the macronutrient content, and are based on plasma insulin response or inflammatory biomarkers, respectively. The glycemic index (GI) and glycemic load (GL) assess postprandial glycemic potential based on dietary carbohydrate content. We tested the hypothesis that dietary patterns promoting hyperinsulinemia, chronic inflammation, or hyperglycemia may influence type 2 diabetes risk. We calculated dietary scores from baseline (1993–1998) food frequency questionnaires among 73,495 postmenopausal women in the Women’s Health Initiative, followed through March 2019. We used multivariable-adjusted Cox regression to estimate hazard ratios (HRs) and 95% CIs for type 2 diabetes risk. We also estimated multivariable-adjusted absolute risk of type 2 diabetes. During a median 13.3 years of follow-up, 11,009 incident cases of type 2 diabetes were diagnosed. Participants consuming the most hyperinsulinemic or proinflammatory dietary patterns experienced greater risk of type 2 diabetes; HRs (95% CI) comparing highest to lowest dietary index quintiles were EDIH 1.49 (1.32–1.68; Ptrend < 0.0001) and EDIP 1.45 (1.29–1.63; Ptrend < 0.0001). The absolute excess incidence for the same comparison was 220 (EDIH) and 271 (EDIP) cases per 100,000 person-years. GI and GL were not associated with type 2 diabetes risk: GI 0.99 (0.88–1.12; Ptrend = 0.46) and GL 1.01 (0.89–1.16; Ptrend = 0.30). Our findings in this diverse cohort of postmenopausal women suggest that lowering the insulinemic and inflammatory potentials of the diet may be more effective in preventing type 2 diabetes than focusing on glycemic foods.
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影响因子：
16.2
作者：
Greenwood DC;Threapleton DE;Evans CE;Cleghorn CL;Nykjaer C;Woodhead C;Burley VJ
通讯作者：
Burley VJ
影响因子：
--
作者：
Liu, Simin;Tinker, Lesley;Manson, JoAnn E.
通讯作者：
Manson, JoAnn E.
DOI：
10.1016/j.jnim.2019.100095
发表时间：
2019-06-01
期刊：
Journal of nutrition & intermediary metabolism
影响因子：
--
作者：
Guinter, Mark A;Merchant, Anwar T;Steck, Susan E
通讯作者：
Steck, Susan E
影响因子：
5.6
作者：
Parker, Emily D.;Liu, Simin;Van Horn, Linda;Tinker, Leslie F.;Shikany, James M.;Eaton, Charles B.;Margolis, Karen L.
通讯作者：
Margolis, Karen L.
影响因子：
2.7
作者：
Margolis, Karen L.;Qi, Lihong;Phillips, Lawrence S.
通讯作者：
Phillips, Lawrence S.