Histocompatibility testing for keratoplasty in high-risk patients.
Histocompatibility testing for keratoplasty in high-risk patients.
复制标题
高危患者角膜移植术的组织相容性测试。
DOI：
10.1016/s0161-6420(83)34575-9
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发表时间：
1983
期刊：
影响因子：
13.7
通讯作者：
Dawson,DV
中科院分区：
文献类型：
--
作者：
Foulks,GN;Sanfilippo,FP;Locascio3rd,JA;MacQueen,JM;Dawson,DV
对48例角膜移植排斥反应高危患者进行角膜移植，角膜移植供体的选择基于阴性淋巴细胞交叉配型、ABO血型相容性和最大化HLA-A、-B配型。将本研究组的移植物存活率与随机获得角膜供体的72例连续高风险移植患者的回顾性对照组进行比较。两组的人口统计学参数、原发疾病的原因和既往移植物排斥反应的发生率没有差异。采用Kaplan-Meier法计算的1年移植物存活率，阴性交叉配型研究组为78%，未交叉配型对照组为52%（P< 0.05%）。交叉配型阴性组中所有移植失败者均为HLA配型差的受者。虽然有证据表明非供体特异性体液对HLA抗原致敏的患者经历了早期移植物排斥反应，但总的移植物存活率与这种非特异性致敏无关。这些发现表明，前瞻性组织相容性测试可以通过更好地识别合适的供体来提高高危患者的角膜移植存活率。
Forty-eight consecutive patients at high risk for corneal graft rejection were transplanted with corneas from donors selected on the basis of a negative lymphocyte crossmatch, ABO blood group compatibility, and maximized HLA-A, -B matching. Graft survival in this study group was compared to a retrospective control group of 72 consecutive high-risk transplants performed in patients receiving randomly obtained corneal donors. Demographic parameters, cause of primary disease, and incidence of prior graft rejection were no different between the two groups. Graft survival at one year, calculated by the Kaplan-Meier method, was 78% for the negative crossmatch study group vs 52% in the uncrossmatched control group (P< 0.05%). All graft failures in the negative crossmatch group were in poorly HLA matched recipients. While patients with evidence of nondonor specific humoral presensitization to HLA antigens experienced earlier graft rejection, overall graft survival was not associated with such nonspecific presensitization. These findings indicate that prospective histocompatibility testing can improve corneal allograft survival for high-risk patients by better identification of appropriate donors.
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64.5
作者：
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影响因子：
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作者：
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影响因子：
3.4
作者：
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影响因子：
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作者：
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Friedman,LR
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DOI：
10.1016/0006-291x(82)91098-1
发表时间：
1982
影响因子：
3.1
作者：
H. Niggli;P. Cerutti
通讯作者：
P. Cerutti