Individual differences in the motivation to communicate relate to levels of midbrain and striatal catecholamine markers in male European starlings.
Individual differences in the motivation to communicate relate to levels of midbrain and striatal catecholamine markers in male European starlings.
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DOI：
10.1016/j.yhbeh.2011.08.001
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发表时间：
2011-11
影响因子：
3.5
通讯作者：
Riters, Lauren V.
中科院分区：
文献类型：
--
作者：
Heimovics, Sarah A.;Salvante, Katrina G.;Sockman, Keith W.;Riters, Lauren V.
关键词：
即使在相似的社会环境中，个体在社会沟通方面也表现出巨大的差异。在脊椎动物中，来自腹侧被盖区（VTA）和中脑中央灰区（GCt）的多巴胺能投射强烈影响动机，奖励导向行为。去甲肾上腺素也富含这些区域，并可能改变多巴胺神经元的活动。本研究旨在探讨多巴胺和去甲肾上腺素在VTA和GCt及其发出纹状体靶区——歌曲控制区X区调控歌唱动机个体差异中的作用。采用高压液相色谱-电化学检测的方法测定了雄性欧洲椋鸟（Sturnus vulgaris） VTA、GCt和X区微孔样品中多巴胺、去甲肾上腺素及其代谢物的含量。我们将雄性分为性动机和非性动机，这是基于对雌性做出反应时发出的歌声的个体差异。VTA和X区的多巴胺标记物和去甲肾上腺素与性动机歌曲呈正相关。X区的去甲肾上腺素与非性动机歌曲呈负相关。GCt中多巴胺与性动机歌曲呈负相关，代谢物DOPAC与非性动机歌曲呈正相关。结果强调了进化上保守的从VTA到纹状体的多巴胺能投射在交流动机中的作用，并强调了X区、VTA和GCt中儿茶酚胺活性的新模式与性动机和非性动机交流的个体差异相关。多巴胺和去甲肾上腺素标志物之间的相关性也表明，去甲肾上腺素可能通过改变VTA和GCt中多巴胺神经元的活性来促进个体之间的交流差异。
Individuals display dramatic differences in social communication even within similar social contexts. Across vertebrates dopaminergic projections from the ventral tegmental area (VTA) and midbrain central gray (GCt) strongly influence motivated, reward-directed behaviors. Norepinephrine is also rich in these areas and may alter dopamine neuronal activity. The present study was designed to provide insight into the roles of dopamine and norepinephrine in VTA and GCt and their efferent striatal target, song control region area X, in the regulation of individual differences in the motivation to sing. We used high pressure liquid chromatography with electrochemical detection to measure dopamine, norepinephrine and their metabolites in micropunched samples from VTA, GCt, and area X in male European starlings (Sturnus vulgaris). We categorized males as sexually motivated or non-sexually motivated based on individual differences in song produced in response to a female. Dopamine markers and norepinephrine in VTA and dopamine in area X correlated positively with sexually-motivated song. Norepinephrine in area X correlated negatively with non-sexually-motivated song. Dopamine in GCt correlated negatively with sexually-motivated song, and the metabolite DOPAC correlated positively with non-sexually-motivated song. Results highlight a role for evolutionarily conserved dopaminergic projections from VTA to striatum in the motivation to communicate and highlight novel patterns of catecholamine activity in area X, VTA, and GCt associated with individual differences in sexually-motivated and non-sexually-motivated communication. Correlations between dopamine and norepinephrine markers also suggest that norepinephrine may contribute to individual differences in communication by modifying dopamine neuronal activity in VTA and GCt.
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影响因子：
2.5
作者：
BOTTJER, SW;HALSEMA, KA;MIESNER, EA
通讯作者：
MIESNER, EA
影响因子：
5.3
作者：
Ding, L;Perkel, DJ
通讯作者：
Perkel, DJ
DOI：
10.1196/annals.1298.043
发表时间：
2004-01-01
期刊：
BEHAVIORAL NEUROBIOLOGY OF BIRDSONG
影响因子：
--
作者：
Ball, GF;Auger, CJ;Balthazart, J
通讯作者：
Balthazart, J
影响因子：
0.7
作者：
EENS, M;PINXTEN, R;VERHEYEN, RF
通讯作者：
VERHEYEN, RF
影响因子：
1.3
作者：
EENS, M;PINXTEN, R;VERHEYEN, RF
通讯作者：
VERHEYEN, RF