Body fat distribution, menopausal hormone therapy and incident type 2 diabetes in postmenopausal women of the MESA study.
Body fat distribution, menopausal hormone therapy and incident type 2 diabetes in postmenopausal women of the MESA study.
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MESA 研究中绝经后女性的身体脂肪分布、绝经期激素治疗和 2 型糖尿病发生情况。
DOI：
10.1016/j.maturitas.2016.06.020
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发表时间：
2016
期刊：
影响因子：
4.9
通讯作者：
Bertoni,AlainG
中科院分区：
文献类型：
--
作者：
Ebong,ImoA;Watson,KarolE;Hairston,KristenG;Carnethon,MercedesR;Ouyang,Pamela;Szklo,Moyses;Bertoni,AlainG
目的探讨绝经后妇女绝经期激素治疗（MHT）与2型糖尿病发病的关系，并探讨体脂分布在这一关系中的潜在调节作用。方法：我们从多民族动脉粥样硬化研究中招募了2210名绝经后无糖尿病的女性（2000 ~ 2002年）。采用Cox比例风险模型检验MHT和MHT类型与糖尿病的关系，根据体脂分布检验差异。结果在11.1年的中位随访中，有226例糖尿病发生。与中枢性或全身性体胖没有显著的相互作用。在完全调整的模型中，当前和过去使用MHT与更高的糖尿病发生风险相关[HR分别为1.66（1.18±2.35）和1.60(1.11±2.30)]。雌激素单一（ET）和黄体酮和雌激素联合（PET）制剂同样与更高的糖尿病发生风险相关[HR分别为1.52（1.03±2.24）和1.77(1.15±2.72)]。结论：在我们对中老年、非糖尿病绝经后妇女的观察性研究中，目前或过去使用MHT与更大的糖尿病发生风险独立相关。ET和PET与绝经后妇女发生糖尿病的风险相似。无论身体质量指数（BMI）或腰围如何，MHT的使用与糖尿病发病率的关联是相同的。
ObjectivesWe investigated the association between menopausal hormone therapy (MHT) and incident type 2 diabetes in postmenopausal women, and explored the potential modifying role of body fat distribution on this association.MethodsWe included 2210 postmenopausal women without prevalent diabetes at recruitment (2000⿿2002) from the Multiethnic Study of Atherosclerosis. Cox proportional hazards models were used to examine associations of MHT and MHT types with incident diabetes, testing for variation according to body fat distribution.ResultsOver a median follow-up of 11.1 years, there were 226 incident cases of diabetes. There were no significant interactions with central or generalized body fatness. In fully adjusted models, current and past MHT use was associated with a greater risk of incident diabetes [HR: 1.66 (1.18⿿2.35) and 1.60 (1.11⿿2.30) respectively]. Estrogen only (ET) and combined progestin and estrogen (PET) formulations were similarly associated with a greater risk of incident diabetes [HR: 1.52 (1.03⿿2.24) and 1.77 (1.15⿿2.72) respectively].ConclusionsIn our observational study of middle-aged and older, non-diabetic postmenopausal women, a current or past use of MHT was independently associated with a greater risk of incident diabetes. ET and PET are associated with similar risks of incident diabetes in postmenopausal women. The association of MHT use with incident diabetes is the same irrespective of body mass index (BMI) or waist circumference.
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影响因子：
2.6
作者：
CerasoliJr,F;Gee,MH;Ishihara,Y;Albertine,KH;Tahamont,MV;Gottlieb,JE;Peters,SP
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影响因子：
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