Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism.
Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism.
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DOI：
10.1093/ije/dyy153
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发表时间：
2018-12-01
影响因子：
7.7
通讯作者：
EMPHASIS study group
中科院分区：
文献类型：
--
作者：
James P;Sajjadi S;Tomar AS;Saffari A;Fall CHD;Prentice AM;Shrestha S;Issarapu P;Yadav DK;Kaur L;Lillycrop K;Silver M;Chandak GR;EMPHASIS study group
越来越多的证据表明，怀孕期间的营养暴露会影响胎儿的表观基因组，这些表观遗传变化可以在出生后持续，并影响整个生命过程中的疾病风险。我们使用三部分搜索策略来回顾人类代际研究。研究1调查了怀孕前或怀孕期间的营养暴露，重点是单碳代谢和后代DNA甲基化之间的关系。Search 2考虑了在第一次搜索中发现的后代DNA甲基化与生长相关、心脏代谢和认知结果之间的关系。Search 3分离了那些通过DNA甲基化将母亲营养暴露与后代表型明确联系起来的研究。最后，我们汇编了搜索中确定的所有候选基因和感兴趣的区域，并描述了它们在Illumina Infinium甲基化珠芯片阵列上的基因组位置、注释和覆盖范围。我们总结了第一次搜索中发现的34项研究、第二次搜索中发现的31项研究和第三次搜索中发现的8项研究的结果。我们提供了这篇综述捕获的45个基因中所有感兴趣区域的详细信息。许多研究已经将印记基因作为优先基因座进行了研究，但随着基于微阵列平台的采用，其他候选基因和基因类别现在正在涌现。尽管有丰富的信息，但目前的文献以不同的暴露和结果为特征，并且大多包括经常被削弱的观察性关联。这项综述提供的现有知识的综合确定了在开发可能的早期生活干预措施以优化终身健康的道路上的研究需求。
Mounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course. We review human intergenerational studies using a three-part search strategy. Search 1 investigates associations between preconceptional or pregnancy nutritional exposures, focusing on one-carbon metabolism, and offspring DNA methylation. Search 2 considers associations between offspring DNA methylation at genes found in the first search and growth-related, cardiometabolic and cognitive outcomes. Search 3 isolates those studies explicitly linking maternal nutritional exposure to offspring phenotype via DNA methylation. Finally, we compile all candidate genes and regions of interest identified in the searches and describe their genomic locations, annotations and coverage on the Illumina Infinium Methylation beadchip arrays. We summarize findings from the 34 studies found in the first search, the 31 studies found in the second search and the eight studies found in the third search. We provide details of all regions of interest within 45 genes captured by this review. Many studies have investigated imprinted genes as priority loci, but with the adoption of microarray-based platforms other candidate genes and gene classes are now emerging. Despite a wealth of information, the current literature is characterized by heterogeneous exposures and outcomes, and mostly comprise observational associations that are frequently underpowered. The synthesis of current knowledge provided by this review identifies research needs on the pathway to developing possible early life interventions to optimize lifelong health.
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影响因子：
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作者：
Bibikova, Marina;Barnes, Bret;Shen, Richard
通讯作者：
Shen, Richard
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Bouwland-Both MI;van Mil NH;Stolk L;Eilers PH;Verbiest MM;Heijmans BT;Tiemeier H;Hofman A;Steegers EA;Jaddoe VW;Steegers-Theunissen RP
通讯作者：
Steegers-Theunissen RP
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影响因子：
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Lillycrop, Karen A.
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作者：
Burris, Heather H.;Baccarelli, Andrea A.;Tellez-Rojo, Martha M.
通讯作者：
Tellez-Rojo, Martha M.
影响因子：
9.3
作者：
Bujold, David;Morais, David Anderson de Lima;Bourque, Guillaume
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Bourque, Guillaume