Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila.
Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila.
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DOI：
10.1038/ncomms6778
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发表时间：
2014-12-15
影响因子：
16.6
通讯作者：
Niwa, Ryusuke
中科院分区：
文献类型：
--
作者：
Shimada-Niwa, Yuko;Niwa, Ryusuke
在营养环境的背景下，发育的时间过渡是灵活协调的，这种协调对于生物体提高生存适应性和繁殖成功率至关重要。类固醇激素是青少年向成年人过渡的关键因素，以营养依赖的方式生物合成;然而，潜在的遗传机制仍不清楚。在这里，我们报告的昆虫类固醇激素，蜕皮激素的生物合成，是由果蝇的一个子集的类固醇能神经元的调节。这些神经元直接支配前胸腺（PG），一个蜕皮激素产生器官，并与口胃神经系统共享管道。有趣的是，突出的神经突在形态上对营养条件做出反应。此外，PG神经支配神经元或PG中5-羟色胺信号传导的活性降低与发育过渡延迟密切相关。我们的研究结果表明，类固醇激素能神经元形成外部环境和内部内分泌系统之间的联系，自适应调整类固醇激素的生物合成的时间。 类固醇激素在从幼年到成年的发育阶段的过渡中起着重要作用。在这里，Shimada-Niwa和Niwa表明，黑腹果蝇的前胸腺中一种这样的激素的产生是由支配前胸腺的一组多巴胺能神经元调节的。
The temporal transition of development is flexibly coordinated in the context of the nutrient environment, and this coordination is essential for organisms to increase their survival fitness and reproductive success. Steroid hormone, a key player of the juvenile-to-adult transition, is biosynthesized in a nutrient-dependent manner; however, the underlying genetic mechanism remains unclear. Here we report that the biosynthesis of insect steroid hormone, ecdysteroid, is regulated by a subset of serotonergic neurons in Drosophila melanogaster. These neurons directly innervate the prothoracic gland (PG), an ecdysteroid-producing organ and share tracts with the stomatogastric nervous system. Interestingly, the projecting neurites morphologically respond to nutrient conditions. Moreover, reduced activity of the PG-innervating neurons or of serotonin signalling in the PG strongly correlates with a delayed developmental transition. Our results suggest that serotonergic neurons form a link between the external environment and the internal endocrine system by adaptively tuning the timing of steroid hormone biosynthesis. Steroidal hormones play a major role in the transition from juvenile-to-adult stages of development. Here, Shimada-Niwa and Niwa show that production of one such hormone in the prothoracic gland of Drosophila melanogaster, is regulated by a subset of serotonergic neurons innervating the prothoracic gland.
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影响因子：
3.7
作者：
Becnel J;Johnson O;Luo J;Nässel DR;Nichols CD
通讯作者：
Nichols CD
DOI：
10.1016/j.cub.2010.01.038
发表时间：
2010-03-09
期刊：
Current biology : CB
影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
Leopold, Pierre
影响因子：
4.6
作者：
Carvalho, Maria;Schwudke, Dominik;Eaton, Suzanne
通讯作者：
Eaton, Suzanne
影响因子：
4.6
作者：
Gibbens, Ying Y.;Warren, James T.;O'Connor, Michael B.
通讯作者：
O'Connor, Michael B.