Folate, Vitamin B6, and Vitamin B12 Status in Association With Metabolic Syndrome Incidence.
Folate, Vitamin B6, and Vitamin B12 Status in Association With Metabolic Syndrome Incidence.
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叶酸，维生素B6和维生素B12状态与代谢综合征的发生率相关。
DOI：
10.1001/jamanetworkopen.2022.50621
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发表时间：
2023-01-03
影响因子：
13.8
通讯作者：
Kahe, Ka
中科院分区：
文献类型：
--
作者：
Zhu, Jie;Chen, Cheng;Lu, Liping;Shikany, James M.;D'Alton, Mary E.;Kahe, Ka
这项队列研究评估了叶酸、维生素B6和维生素B12状态与美国成年人代谢综合征发病率之间的关系。叶酸、维生素B6和维生素B12的摄入量和血清水平与美国人群中代谢综合征（MetS）的发病率相关吗？在这项4414名美国成年人的队列研究中，叶酸、维生素B6和维生素B12的摄入量和血清浓度与美国黑人和白色年轻人的代谢综合征发病率呈负相关。这些发现表明，应推荐摄入足够的叶酸、维生素B6和维生素B12来预防MetS。在美国人群中，B族维生素状态与代谢综合征（MetS）发病率的关系尚不清楚。在一个大型美国队列中研究叶酸、维生素B6和维生素B12的摄入量和血清浓度与代谢综合征风险的相关性。这项前瞻性研究包括1985年至1986年入组的美国黑人和白色年轻人，研究持续至2015年至2016年。在检查第0、7和20年，使用经验证的饮食史评估饮食。叶酸，维生素B6和维生素B12的血清浓度进行了测定，在检查年0，7和15在一个子集的1430名参与者。MetS通过临床和实验室测量以及自我报告的药物使用来确定。数据分析时间为2021年1月至7月。叶酸、维生素B6和维生素B12的摄入量和血清水平。采用多变量考克斯比例风险回归模型计算能量调整后的B族维生素摄入量或血清B族维生素水平与代谢综合征发生率之间的风险比（HR）和95% CI。该研究包括4414名参与者，其中2225名黑人（50.4%）和2331名女性（52.8%）。基线时的平均（SD）年龄为24.9（3.6）岁。在30年（平均值[SD]，22.1 [9.5]年）的随访期间，共发生1240例MetS事件。与每种能量调整后的B族维生素摄入量最低的五分位数相比，最高五分位数中发生代谢综合征的HR为0.39叶酸（95% CI，0.31-0.49）（趋势P < .001），0.61维生素B6（95% CI，0.46-0.81）（趋势P = 0.002），维生素B12（趋势P = 0.008）校正潜在混杂因素后为0.74（95% CI，0.58-0.95）。同样，在这些B族维生素的血清数据亚组中观察到显著的负相关（叶酸：HR，0.23; 95%CI，0.17-0.33; P趋势< .001;维生素B6：HR，0.48; 95%CI，0.34-0.67; P趋势< .001;维生素B12：HR，0.70; 95% CI，0.51-0.96;趋势P = .01）。这项前瞻性队列研究发现，叶酸、维生素B6和维生素B12的摄入量和血清浓度与美国黑人和白色年轻人中MetS的发生率呈负相关。
This cohort study evaluates the association between folate, vitamin B6, and vitamin B12 status and metabolic syndrome incidence among US adults. Are intakes and serum levels of folate, vitamin B6, and vitamin B12 associated with metabolic syndrome (MetS) incidence among the US population? In this cohort study of 4414 US adults, intakes and serum concentrations of folate, vitamin B6, and vitamin B12 were inversely associated with incident MetS among Black and White young adults in the US. These findings suggest that adequate intakes of folate, vitamin B6, and vitamin B12 should be recommended for prevention of MetS. The associations of B vitamin status with metabolic syndrome (MetS) incidence among the US population remain unclear. To investigate intakes and serum concentrations of folate, vitamin B6, and vitamin B12 in association with MetS risk in a large US cohort. This prospective study included Black and White young adults in the US who were enrolled from 1985 to 1986 and studied until 2015 to 2016. Diet was assessed using a validated diet history at examination years 0, 7, and 20. Serum concentrations of folate, vitamin B6, and vitamin B12 were assayed at examination years 0, 7, and 15 in a subset of 1430 participants. MetS was ascertained by clinic and laboratory measurements and self-reported medication use. Data were analyzed between January and July 2021. Intakes and serum levels of folate, vitamin B6, and vitamin B12. Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% CIs for the associations of energy-adjusted B vitamin intakes or serum B vitamin levels with incident MetS. The study included 4414 participants, with 2225 Black individuals (50.4%) and 2331 women (52.8%). The mean (SD) age at baseline was 24.9 (3.6) years. A total of 1240 incident MetS cases occurred during the 30 years (mean [SD], 22.1 [9.5] years) of follow-up. Compared with the lowest quintile of each energy-adjusted B vitamin intake, the HRs for incident MetS in the highest quintile were 0.39 (95% CI, 0.31-0.49) for folate (P for trend < .001), 0.61 (95% CI, 0.46-0.81) for vitamin B6 (P for trend = .002), and 0.74 (95% CI, 0.58-0.95) for vitamin B12 (P for trend = .008) after adjustment for potential confounders. Similarly, significant inverse associations were observed in the subset with serum data on these B vitamins (folate: HR, 0.23; 95% CI, 0.17-0.33; P for trend < .001; vitamin B6: HR, 0.48; 95% CI, 0.34-0.67; P for trend < .001; and vitamin B12: HR, 0.70; 95% CI, 0.51-0.96; P for trend = .01). This prospective cohort study found that intakes and serum concentrations of folate, vitamin B6, and vitamin B12 were inversely associated with incident MetS among Black and White young adults in the US.
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微量营养素的摄入量和代谢综合征的存在。
DOI：
10.4103/1947-2714.114171
发表时间：
2013-06
期刊：
North American journal of medical sciences
影响因子：
--
作者：
Motamed S;Ebrahimi M;Safarian M;Ghayour-Mobarhan M;Mouhebati M;Azarpazhouh M;Esmailie H;Norouzi A;Ferns GA
通讯作者：
Ferns GA
影响因子：
16.2
作者：
Li, Mengying;Li, Shanshan;Zhang, Cuilin
通讯作者：
Zhang, Cuilin
影响因子：
5.3
作者：
Folsom, AR;Desvarieux, M;Chambless, LE
通讯作者：
Chambless, LE
影响因子：
1.6
作者：
Wang, Jin;Xu, Lijuan;Tang, Shiqi
通讯作者：
Tang, Shiqi
DOI：
10.1097/00008483-198911000-00003
发表时间：
1989-11-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
--
作者：
Jacobs, David R Jr;Hahn, Lorraine P;Sidney, Stephen
通讯作者：
Sidney, Stephen