Continuous in-home monitoring of essential tremor.
Continuous in-home monitoring of essential tremor.
复制标题
对必需震颤的连续内部监测。
DOI：
10.1016/j.parkreldis.2013.09.009
复制
发表时间：
2014-01
影响因子：
4.1
通讯作者：
Heldman DA
中科院分区：
文献类型：
--
作者：
Pulliam CL;Eichenseer SR;Goetz CG;Waln O;Hunter CB;Jankovic J;Vaillancourt DE;Giuffrida JP;Heldman DA
特发性震颤（ET）通常在临床使用主观震颤评定量表进行测量，需要临床医生在场评分，不适合全天测量严重程度。在实验室中，运动传感器可以在一系列预先设定的任务中准确地评估震颤的严重程度。我们评估了运动传感器在家中自由活动时量化震颤的能力。20名ET受试者连续两天每天佩戴无线传感器长达10小时，并每小时完成包括预定义任务的标准化震颤评估。使用数学模型从传感器数据预测震颤等级分数。每小时标准化评估的家庭震颤评分与标准化评估后立即进行的无约束活动中估计的家庭震颤评分相关。每小时的标准化摊款在一天中没有显著波动，而连续摊款的波动往往随自愿活动水平的变化而变化。两种类型的震颤等级（标准化和连续）都显示出较高的日常测试-重测信度，连续等级的类内相关系数为0.67至0.90，标准化等级的类内相关系数为0.77至0.95。结果表明，在家连续监测震颤严重程度的可行性，可为临床医生提供日常生活中震颤时间模式的测量方法，并可作为临床试验中评估新型抗震颤药物的有用工具。
Essential tremor (ET) is typically measured in the clinic with subjective tremor rating scales which require the presence of a clinician for scoring and are not appropriate for measuring severity throughout the day. Motion sensors can accurately rate tremor severity during a set of predefined tasks in a laboratory. We evaluated the ability of motion sensors to quantify tremor during unconstrained activities at home. 20 ET subjects wore a wireless sensor continuously for up to 10 hours daily on two days and completed hourly standardized tremor assessments involving pre-defined tasks. Mathematical models were used to predict tremor rating scores from the sensor data. At home tremor scores from hourly standardized assessments correlated with at home tremor scores estimated during unconstrained activities immediately following the standardized assessments. The hourly standardized assessments did not significantly fluctuate throughout the day, while fluctuations in the continuous assessments tended to follow changes in voluntary activity level. Both types of tremor ratings (standardized and continuous) showed high day-to-day test-retest reliability with intraclass correlation coefficients ranging from 0.67 to 0.90 for continuous ratings and 0.77 to 0.95 for standardized ratings. Results demonstrate the feasibility of continuous monitoring of tremor severity at home, which should provide clinicians with a measure of the temporal pattern of tremor in the context of daily life and serve as a useful tool for the evaluation of novel anti-tremor medications in clinical trials.
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影响因子：
8.6
作者：
Elble, Rodger;Comella, Cynthia;Fahn, Stanley;Hallett, Mark;Jankovic, Joseph;Juncos, Jorge L.;LeWitt, Peter;Lyons, Kelly;Ondo, William;Pahwa, Rajesh;Sethi, Kapil;Stover, Natividad;Tarsy, Daniel;Testa, Claudia;Tintner, Ron;Watts, Ray;Zesiewicz, Theresa
通讯作者：
Zesiewicz, Theresa
影响因子：
9.9
作者：
Vaillancourt, DE;Sturman, MM;Corcos, DM
通讯作者：
Corcos, DM
影响因子：
8.6
作者：
Giuffrida, Joseph P.;Riley, David E.;Heldman, Dustin A.
通讯作者：
Heldman, Dustin A.
影响因子：
8.6
作者：
Mostile, Giovanni;Giuffrida, Joseph P.;Jankovic, Joseph
通讯作者：
Jankovic, Joseph
影响因子：
3.5
作者：
Hariz, G.-M.;Blomstedt, P.;Koskinen, L.-O. D.
通讯作者：
Koskinen, L.-O. D.