Culture-independent microbiological analysis of foley urinary catheter biofilms.
Culture-independent microbiological analysis of foley urinary catheter biofilms.
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DOI：
10.1371/journal.pone.0007811
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发表时间：
2009-11-12
期刊：
影响因子：
3.7
通讯作者：
Pace NR
中科院分区：
文献类型：
--
作者：
Frank DN;Wilson SS;St Amand AL;Pace NR
导尿管相关性尿路感染（CAUTI）是院内疾病的主要原因，细菌在留置医疗器械上形成生物膜的倾向使其预防复杂化。为了更好地了解这些群落的微生物多样性，我们报告了对全前列腺切除术后患者的Foley导尿管进行培养独立细菌调查的结果。根据康复期间是否接受过全身性氟喹诺酮类抗生素治疗，对两个患者亚群进行了分析。结果表明，在未接受全身抗生素治疗的患者中最常观察到多种多微生物组合的存在。这些群落通常含有革兰氏阳性和革兰氏阴性微生物，其中包括多种潜在病原体。CAUTI的预防和治疗必须考虑到任何特定感染可能的多微生物性质。
Prevention of catheter-associated urinary tract infection (CAUTI), a leading cause of nosocomial disease, is complicated by the propensity of bacteria to form biofilms on indwelling medical devices. To better understand the microbial diversity of these communities, we report the results of a culture-independent bacterial survey of Foley urinary catheters obtained from patients following total prostatectomy. Two patient subsets were analyzed, based on treatment or no treatment with systemic fluoroquinolone antibiotics during convalescence. Results indicate the presence of diverse polymicrobial assemblages that were most commonly observed in patients who did not receive systemic antibiotics. The communities typically contained both Gram-positive and Gram-negative microorganisms that included multiple potential pathogens. Prevention and treatment of CAUTI must take into consideration the possible polymicrobial nature of any particular infection.
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