Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate
Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate
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Trnp1 通过控制径向胶质细胞命运来调节哺乳动物大脑皮层的扩张和折叠
DOI：
10.1016/j.cell.2013.03.027
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发表时间：
2013
期刊：
影响因子：
64.5
通讯作者：
Götz M
中科院分区：
文献类型：
--
作者：
Stahl R;Walcher T;De Juan Romero C;Pilz GA;Cappello S;Irmler M;Sanz-Aquela JM;Beckers J;Blum R;Borrell V;Götz M
哺乳动物大脑的进化包括大脑皮层尺寸的显著增加，包括切向和径向扩张。然而，这些关键特征背后的机制在很大程度上仍然未知。在这里，我们确定了DNA相关蛋白Trnp1作为大脑皮层扩张的调节器在这两个方面。在小鼠大脑皮层中进行的体内功能获得和丧失实验表明，高Trnp1水平促进神经干细胞自我更新和切向扩张。相比之下，较低的水平促进径向扩张，中间祖细胞和基底放射状胶质细胞数量的有效增加导致原本光滑的小鼠大脑皮层折叠。值得注意的是，TRNP 1表达水平在人类胎儿大脑皮层表现出区域差异，预测径向或切向扩张。因此，动态调节ofTrnp1是至关重要的控制切向和径向扩张的大脑皮层在哺乳动物。
Evolution of the mammalian brain encompassed a remarkable increase in size of the cerebral cortex, which includes tangential and radial expansion. However, the mechanisms underlying these key features are still largely unknown. Here, we identified the DNA-associated protein Trnp1 as a regulator of cerebral cortex expansion in both of these dimensions. Gain- and loss-of-function experiments in the mouse cerebral cortex in vivo demonstrate that high Trnp1 levels promote neural stem cell self-renewal and tangential expansion. In contrast, lower levels promote radial expansion, with a potent increase of the number of intermediate progenitors and basal radial glial cells leading to folding of the otherwise smooth murine cerebral cortex. Remarkably,TRNP1expression levels exhibit regional differences in the cerebral cortex of human fetuses, anticipating radial or tangential expansion. Thus, the dynamic regulation ofTrnp1is critical to control tangential and radial expansion of the cerebral cortex in mammals.
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UTF1是与ES细胞分化有关的染色质相关蛋白。
影响因子：
7.8
作者：
van den Boom, Vincent;Kooistra, Susanne M.;Boesjes, Mariie;Geverts, Bart;Houtsmuller, Adriaan B.;Monzen, Koshiro;Komuro, Issei;Essers, Jeroen;Drenth-Diephuis, Loes J.;Eggen, Bart J. L.
通讯作者：
Eggen, Bart J. L.
影响因子：
11.4
作者：
Nonaka-Kinoshita, Miki;Reillo, Isabel;Artegiani, Benedetta;Angeles Martinez-Martinez, Maria;Nelson, Mark;Borrell, Victor;Calegari, Federico
通讯作者：
Calegari, Federico
影响因子：
14.8
作者：
Saito, Tetsuichiro
通讯作者：
Saito, Tetsuichiro
影响因子：
3.7
作者：
Garcia-Moreno, Fernando;Vasistha, Navneet A.;Molnar, Zoltan
通讯作者：
Molnar, Zoltan
DOI：
10.1093/cercor/bhm184
发表时间：
2008-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Bayatti N;Moss JA;Sun L;Ambrose P;Ward JF;Lindsay S;Clowry GJ
通讯作者：
Clowry GJ