Regulation of cerebral cortex size and folding by expansion of basal progenitors.
Regulation of cerebral cortex size and folding by expansion of basal progenitors.
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DOI：
10.1038/emboj.2013.96
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发表时间：
2013-07-03
期刊：
影响因子：
11.4
通讯作者：
Calegari, Federico
中科院分区：
文献类型：
--
作者：
Nonaka-Kinoshita, Miki;Reillo, Isabel;Artegiani, Benedetta;Angeles Martinez-Martinez, Maria;Nelson, Mark;Borrell, Victor;Calegari, Federico
在哺乳动物的进化过程中，大脑皮层的大小和折叠大量增加，导致了目前大脑形态的多样性。神经干细胞和祖细胞的各种亚型已被提出在发育过程中调节大脑皮层的厚度或折叠方面有不同的贡献，但它们的具体作用尚未得到证实。我们报告说，在小鼠胚胎中的单能基底祖细胞的控制扩张导致了巨脑畸形，大脑皮质的表面积增加，但不是皮质折叠。与此相反，在自然脑回雪貂的多能基底祖细胞的扩张足以驱动额外的褶皱和裂缝的形成。在这两个模型中，变化发生时，保留了结构正常的六层皮质。我们的研究结果是第一次实验证明的具体和独特的作用，为基础的基础祖亚型在调节大脑皮层的大小和折叠在发展过程中获得的高等哺乳动物在进化过程中的上级智力能力。
Size and folding of the cerebral cortex increased massively during mammalian evolution leading to the current diversity of brain morphologies. Various subtypes of neural stem and progenitor cells have been proposed to contribute differently in regulating thickness or folding of the cerebral cortex during development, but their specific roles have not been demonstrated. We report that the controlled expansion of unipotent basal progenitors in mouse embryos led to megalencephaly, with increased surface area of the cerebral cortex, but not to cortical folding. In contrast, expansion of multipotent basal progenitors in the naturally gyrencephalic ferret was sufficient to drive the formation of additional folds and fissures. In both models, changes occurred while preserving a structurally normal, six-layered cortex. Our results are the first experimental demonstration of specific and distinct roles for basal progenitor subtypes in regulating cerebral cortex size and folding during development underlying the superior intellectual capability acquired by higher mammals during evolution.
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DOI：
10.1093/cercor/bhr301
发表时间：
2012-02
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Kelava I;Reillo I;Murayama AY;Kalinka AT;Stenzel D;Tomancak P;Matsuzaki F;Lebrand C;Sasaki E;Schwamborn JC;Okano H;Huttner WB;Borrell V
通讯作者：
Borrell V
DOI：
10.1073/pnas.111051398
发表时间：
2001-05-22
影响因子：
11.1
作者：
Mitsuhashi, T;Aoki, Y;Caviness, VS
通讯作者：
Caviness, VS
DOI：
10.1073/pnas.0308600100
发表时间：
2004-03-02
影响因子：
11.1
作者：
Haubensak, W;Attardo, A;Huttner, WB
通讯作者：
Huttner, WB
影响因子：
64.5
作者：
Lui JH;Hansen DV;Kriegstein AR
通讯作者：
Kriegstein AR
DOI：
10.1093/cercor/bhm184
发表时间：
2008-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Bayatti N;Moss JA;Sun L;Ambrose P;Ward JF;Lindsay S;Clowry GJ
通讯作者：
Clowry GJ