Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management.
Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management.
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DOI：
10.3390/nu13061867
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发表时间：
2021-05-30
期刊：
影响因子：
5.9
通讯作者：
Ahmad N
中科院分区：
文献类型：
--
作者：
Singh CK;Chhabra G;Patel A;Chang H;Ahmad N
研究表明微量元素锌（Zn）在前列腺生物学和功能中起着重要作用。锌已被证明在健康的前列腺中以非常高的浓度存在，并且对几种前列腺功能很重要。在前列腺癌（PCa）中，锌水平显著降低，并与疾病进展呈负相关。理想情况下，恢复足够的锌水平在癌前/恶性前列腺细胞可以中止前列腺恶性。然而，研究表明，补充锌并不是显著提高PCa中锌浓度的有效方法。基于有限数量的研究，PCa中锌水平较低的原因被认为是锌转运蛋白（特别是ZIP和ZnT家族蛋白）、金属硫蛋白（用于储存和释放锌）及其调节因子（例如锌指转录因子RREB1）的失调。有趣的是，细胞中锌的水平已被证明是由自然产生的膳食植物化学物质调节的。在这篇综述中，我们讨论了一些植物化学物质（槲皮素、白藜芦醇、表没食子儿茶素-3-没食子酸酯和姜黄素）对锌功能的影响，并提出锌与特定的膳食植物化学物质联合使用可能导致锌在前列腺中的生物积累增加，从而可能抑制前列腺癌。
Studies have suggested an important role of the trace element zinc (Zn) in prostate biology and functions. Zn has been shown to exist in very high concentrations in the healthy prostate and is important for several prostatic functions. In prostate cancer (PCa), Zn levels are significantly decreased and inversely correlated with disease progression. Ideally, restoration of adequate Zn levels in premalignant/malignant prostate cells could abort prostate malignancy. However, studies have shown that Zn supplementation is not an efficient way to significantly increase Zn concentrations in PCa. Based on a limited number of investigations, the reason for the lower levels of Zn in PCa is believed to be the dysregulation of Zn transporters (especially ZIP and ZnT family of proteins), metallothioneins (for storing and releasing Zn), and their regulators (e.g., Zn finger transcription factor RREB1). Interestingly, the level of Zn in cells has been shown to be modulated by naturally occurring dietary phytochemicals. In this review, we discussed the effect of selected phytochemicals (quercetin, resveratrol, epigallocatechin-3-gallate and curcumin) on Zn functioning and proposes that Zn in combination with specific dietary phytochemicals may lead to enhanced Zn bioaccumulation in the prostate, and therefore, may inhibit PCa.
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影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
影响因子：
4.8
作者：
Crawford ED;Heidenreich A;Lawrentschuk N;Tombal B;Pompeo ACL;Mendoza-Valdes A;Miller K;Debruyne FMJ;Klotz L
通讯作者：
Klotz L
影响因子：
5.8
作者：
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通讯作者：
Franklin RB
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4.7
作者：
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通讯作者：
Siddiqui MM
影响因子：
5.9
作者：
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通讯作者：
Majumder K