T-cell surveillance of the human brain in health and multiple sclerosis.
T-cell surveillance of the human brain in health and multiple sclerosis.
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DOI：
10.1007/s00281-022-00926-8
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发表时间：
2022-11
影响因子：
9
通讯作者：
Hamann, Jorg
中科院分区：
文献类型：
--
作者：
Smolders, Joost;van Luijn, Marvin M.;Hsiao, Cheng-Chih;Hamann, Jorg
循环和组织驻留T细胞在保护组织免受有害感染和恶性转化方面合作，但也可以引发自身免疫反应。由于中枢神经系统（CNS）的区室化组织，T细胞在大脑中的类似作用不太明显。近年来，T细胞靶向药物在早期多发性硬化症（MS）患者中的有益和偶然的有害作用增加了对T细胞巡逻CNS的兴趣。除了关注脑脊液中T细胞的研究外，还报道了位于血管周围间隙和脑膜以及MS病变实质中的T细胞的表型特征。我们在这里总结了目前关于T细胞浸润健康和MS大脑的知识，并认为了解T细胞生理CNS监视的动态可能会提高对病理条件（如MS）的理解。
Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS.
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影响因子：
8.8
作者：
Gordon CL;Lee LN;Swadling L;Hutchings C;Zinser M;Highton AJ;Capone S;Folgori A;Barnes E;Klenerman P
通讯作者：
Klenerman P
影响因子：
82.9
作者：
Gattinoni L;Lugli E;Ji Y;Pos Z;Paulos CM;Quigley MF;Almeida JR;Gostick E;Yu Z;Carpenito C;Wang E;Douek DC;Price DA;June CH;Marincola FM;Roederer M;Restifo NP
通讯作者：
Restifo NP
DOI：
10.1038/s41582-020-00427-y
发表时间：
2021-01
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Cortese I;Reich DS;Nath A
通讯作者：
Nath A
影响因子：
7.3
作者：
Bell, Luisa;Lenhart, Alexander;Berberich-Siebelt, Friederike
通讯作者：
Berberich-Siebelt, Friederike
影响因子：
30.5
作者：
Duhen, Thomas;Geiger, Rebekka;Sallusto, Federica
通讯作者：
Sallusto, Federica