In vivo spectral editing of phosphorylethanolamine.
In vivo spectral editing of phosphorylethanolamine.
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DOI：
10.1002/mrm.28976
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发表时间：
2022-01
影响因子：
3.3
通讯作者：
Saleh MG
中科院分区：
文献类型：
--
作者：
Hui SCN;Zöllner HJ;Oeltzschner G;Edden RAE;Saleh MG
为了演示在3.22 （PE3.22）和3.98 (PE3.98) ppm下化学位移对磷酸乙醇胺（PE）的j差编辑，并比较两种编辑策略的优点，我们在80至200 ms的TEs范围内以2 ms的步长进行了MEGA-PRESS对PE的密度矩阵模拟，应用20 ms的编辑脉冲（ON/OFF）在3.98/7.5 ppm下检测PE3.22；b) 3.22/7.5 ppm检测PE3.98。利用PE模型进行仿真实验，验证仿真结果。10名受试者在TEs（90和110 ms）使用Philips 3T MRI扫描仪扫描，编辑PE3.22和PE3.98。鱼鹰被用于数据处理、建模和量化。仿真表明，由于耦合演化，编辑信号的强度和形状发生了实质性的te调制。模拟积分和模拟积分表明，对于编辑检测PE3.22和PE3.98, 110 ms和90 ms的te分别是最优的。模拟结果与模拟的光谱和积分非常吻合。PE3.22/tCr和PE3.98/tCr在体内的浓度比在测试90 ms时分别为0.26±0.04（受试者间变异系数，CV: 15.4%）和0.18±0.04 (CV: 22.8%)，在测试110 ms时分别为0.24±0.02 （CV: 8.2%）和0.23±0.04 （CV: 18.0%）。PE的模拟和体内MEGA-PRESS表明，PE3.22和PE3.98都是潜在的编辑候选物，但PE3.22在TE 110 ms时产生的差异较小。
To demonstrate J-difference editing of phosphorylethanolamine (PE) with chemical shifts at 3.22 (PE3.22) and 3.98 (PE3.98) ppm, and compare the merits of two editing strategies Density-matrix simulations of MEGA-PRESS for PE were performed at TEs ranging from 80 to 200 ms in steps of 2 ms, applying 20 ms editing pulses (ON/OFF) at: a) 3.98/7.5 ppm to detect PE3.22; and b) 3.22/7.5 ppm to detect PE3.98. Phantom experiments were performed using a PE phantom to validate simulation results. 10 subjects were scanned using a Philips 3T MRI scanner at TEs (90 and 110 ms) to edit PE3.22 and PE3.98. Osprey was used for data processing, modeling, and quantification. Simulations show substantial TE-modulation of the intensity and shape of the edited signals due to coupling evolution. Simulated and phantom integrals suggest that TEs of 110 and 90 ms were optimal for the edited detection of PE3.22 and PE3.98, respectively. Phantom results indicated strong agreement with the simulated spectra and integrals. In vivo quantification of the PE3.22/tCr and PE3.98/tCr concentration ratio yielded values of 0.26 ± 0.04 (between-subject coefficient of variation, CV: 15.4%) and 0.18 ± 0.04 (CV: 22.8%), respectively at TE 90 ms, and 0.24 ± 0.02 (CV: 8.2%) and 0.23 ± 0.04 (CV: 18.0%) respectively at TE 110 ms. Simulations and in vivo MEGA-PRESS of PE demonstrate both PE3.22 and PE3.98 are potential candidates for editing, but PE3.22 at TE 110 ms yields lower variation across TEs.
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影响因子：
3.3
作者：
Marjańska M;McCarten JR;Hodges J;Hemmy LS;Grant A;Deelchand DK;Terpstra M
通讯作者：
Terpstra M
影响因子：
2.9
作者：
通讯作者：
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影响因子：
2.2
作者：
Cleve, Marianne;Kraemer, Martin;Reichenbach, Juergen R.
通讯作者：
Reichenbach, Juergen R.
影响因子：
2.9
作者：
de Barros, Nuno Pedrosa;Slotboom, Johannes
通讯作者：
Slotboom, Johannes
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影响因子：
4.4
作者：
Edden, Richard A. E.;Oeltzschner, Georg;Harris, Ashley D.;Puts, Nicolaas A. J.;Chan, Kimberly L.;Boer, Vincent O.;Schar, Michael;Barker, Peter B.
通讯作者：
Barker, Peter B.