MicroRNAs in insulin resistance and obesity.
MicroRNAs in insulin resistance and obesity.
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DOI：
10.1155/2012/484696
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发表时间：
2012
影响因子：
--
通讯作者：
Mitchell GM
中科院分区：
文献类型：
--
作者：
Williams MD;Mitchell GM
MicroRNA（miRNA）是一类短的单链非蛋白质编码基因产物，可以通过转录后抑制信使RNA（mRNA）翻译来调节基因表达。已知它们参与许多重要的生物过程，包括发育、胰岛素分泌和脂肪细胞分化。 miRNA 参与复杂的代谢过程，例如能量和脂质代谢，这些过程已在糖尿病和肥胖的背景下进行了研究。肥胖、高脂血症（血脂水平升高）和胰岛素抵抗与 2 型糖尿病的发病密切相关。这些病症还与朗格汉斯胰岛和周围组织（包括脂肪组织）中多种必需 miRNA 的异常表达有关。彻底了解这些 miRNA 在这些组织中发挥的生理作用，以及它们在病理条件下表达的变化，将使研究人员能够开发出新的疗法，有可能纠正 2 型糖尿病和肥胖症中 miRNA 的异常表达。
MicroRNAs (miRNAs) are a class of short, single-stranded non-protein coding gene products which can regulate the gene expression through post-transcriptional inhibition of messenger RNA (mRNA) translation. They are known to be involved in many essential biological processes including development, insulin secretion, and adipocyte differentiation. miRNAs are involved in complex metabolic processes, such as energy and lipid metabolism, which have been studied in the context of diabetes and obesity. Obesity, hyperlipidemia (elevated levels of blood lipids), and insulin resistance are strongly associated with the onset of type 2 diabetes. These conditions are also associated with aberrant expression of multiple essential miRNAs in pancreatic islets of Langerhans and peripheral tissues, including adipose tissue. A thorough understanding of the physiological role these miRNAs play in these tissues, and changes to their expression under pathological conditions, will allow researchers to develop new therapeutics with the potential to correct the aberrant expression of miRNAs in type 2 diabetes and obesity.
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DOI：
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发表时间：
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影响因子：
3.1
作者：
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