Prognostic role of pre-treatment serum AFP-L3% in hepatocellular carcinoma: systematic review and meta-analysis.
Prognostic role of pre-treatment serum AFP-L3% in hepatocellular carcinoma: systematic review and meta-analysis.
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预后％20角色％20of％20治疗前％20血清％20AFP-L3％％20in％20肝细胞％20癌：％20％20％20％20％20％20系统％20审查％20和％20荟萃分析。
DOI：
10.1371/journal.pone.0087011
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Cheng J;Wang W;Zhang Y;Liu X;Li M;Wu Z;Liu Z;Lv Y;Wang B
Serum lens culinaris agglutinin-reactive fraction of α-fetoprotein (AFP-L3%) has been widely used for HCC diagnosis and follow-up surveillance as tumor serologic marker. However, the prognostic value of high pre-treatment serum AFP-L3% in patients with hepatocellular carcinoma (HCC) remains controversial. We therefore conduct a meta-analysis to assess the relationship between high pre-treatment serum AFP-L3% and clinical outcome of HCC. Eligible studies were identified through systematic literature searches. A meta-analysis of fifteen studies (4,465 patients) was carried out to evaluate the association between high pre-treatment serum AFP-L3% and overall survival (OS) and disease-free survival (DFS) in HCC patients. Sensitivity and subgroup analyses were also conducted in this meta-analysis. Our analysis results showed that high pre-treatment serum AFP-L3% implied poor OS (HR: 1.65, 95%CI: 1.45–1.89 p<0.00001) and DFS (HR: 1.80, 95% CI: 1.49–2.17 p<0.00001) of HCC. Subgroup analysis revealed that there was association between pre-treatment serum AFP-L3% and endpoint (OS and DFS) in low AFP concentration HCC patients (HR: 1.96, 95% CI: 1.24–3.10, p = 0.004; HR: 2.53, 95% CI: 1.09–5.89, p = 0.03, respectively). The current evidence suggests that high pre-treatment serum AFP-L3% levels indicated a poor prognosis for patients with HCC and AFP-L3% may have significant prognostic value in HCC patients with low AFP concentration.
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DOI：
10.1046/j.1440-1746.2001.02643.x
发表时间：
2001-12-01
影响因子：
4.1
作者：
Oka, H;Saito, A;Tanaka, M
通讯作者：
Tanaka, M
影响因子：
3.5
作者：
Fujiyama, S;Tanaka, M;Tomita, K
通讯作者：
Tomita, K
影响因子：
5.4
作者：
Beppu, Tetsuya;Sugimoto, Kazushi;Takeda, Kan
通讯作者：
Takeda, Kan
影响因子：
2.9
作者：
Kawabata, Tomohisa;Wada, Henry G.;Satomura, Shinji
通讯作者：
Satomura, Shinji
DOI：
10.1111/j.1440-1746.2011.06720.x
发表时间：
2011-07-01
影响因子：
4.1
作者：
Nouso, Kazuhiro;Kobayashi, Yoshiyuki;Yamamoto, Kazuhide
通讯作者：
Yamamoto, Kazuhide