Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans.
Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans.
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DOI：
10.1016/j.jpsychires.2013.02.006
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发表时间：
2013-06
影响因子：
4.8
通讯作者：
Nielsen, David A.
中科院分区：
文献类型：
--
作者：
Graham, David P.;Helmer, Drew A.;Harding, Mark J.;Kosten, Thomas R.;Petersen, Nancy J.;Nielsen, David A.
有证据表明，具有 5-HTTLPR 变异短/短基因型的个体对感知社会支持的积极和消极看法的敏感性增加。本研究的目的是评估退伍军人在轻度创伤性脑损伤 (TBI) 背景下的这种关联。作为大型 TBI 中心的一部分，我们对 67 名 OEF/OIF/OND 退伍军人（41 名患有 TBI 和 26 名对照者没有 TBI）进行了横断面研究，他们填写了问卷并同意进行基因检测。主要衡量标准包括康纳-戴维森复原力量表 (CDRISC) 和服役人员社区重新融入工具 (CRIS-PL) 的社区参与子量表中的感知限制。 5-HTTLPR 基因型和 TBI 状态均与 CRIS-PL（基因型 p = .009，TBI p = .001）和 CDRISC（基因型 p = .015，TBI p = .003）评分独立相关。这项研究表明，5-HTTLPR 基因型和 TBI 状态都独立地以几乎相同但相反的方向影响弹性和社会参与的感知限制。此外，与 L' 基因型携带者相比，携带 S'S' 基因型的退伍军人的恢复力似乎对感知到的限制更敏感，但仅限于遭受 TBI 的情况。虽然患有 TBI 似乎会增加退伍军人对社会压力的敏感性，但患有 TBI 的 L' 等位基因携带者的退伍军人表现最差，与没有 TBI 的 L' 携带者退伍军人或具有 S'S' 基因型的退伍军人（无论 TBI 状态如何）相比，其恢复能力较低，社区参与受到更多限制。
Evidence indicates that individuals with the 5-HTTLPR variant short/short genotype have increased sensitivity to both positive and negative perceptions of perceived social support. The aim of this study was to evaluate this association among Veterans in the context of mild traumatic brain injury (TBI). As part of a larger TBI center, we performed a cross-sectional study of 67 OEF/OIF/OND Veterans (41 with TBI and 26 controls without TBI) who completed the questionnaires and consented to genetic testing. The primary measures included the Connor-Davidson Resilience Scale (CDRISC) and the Perceived Limitations in community participation subscale of the Community Reintegration of Service Members Instrument (CRIS-PL). Both 5-HTTLPR genotype and TBI status were independently associated with the CRIS-PL (p = .009 for genotype, p = .001 for TBI) and the CDRISC (p = .015 for genotype, p = .003 for TBI) scores. This study suggests that both the 5-HTTLPR genotype and TBI status independently, in an almost equal but opposite direction, influence resilience and perceived limitations to social participation. Further, resilience appears more sensitive to perceived limitations in Veterans carrying an S′S′ genotype than in L′ carriers, but only in the context of having sustained a TBI. While having a TBI appeared to increase a Veteran's sensitivity to social stress, the Veteran's who were L′ allele carriers with a TBI fared the worst, with lower resilience and more perceived limitations for community participation compared to L′ carrier Veterans without a TBI or Veterans with the S′S′ genotype regardless of TBI status.
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影响因子：
4.8
作者：
Amstadter AB;Daughters SB;Macpherson L;Reynolds EK;Danielson CK;Wang F;Potenza MN;Gelernter J;Lejuez CW
通讯作者：
Lejuez CW
影响因子：
7.4
作者：
Connor, KM;Davidson, JRT
通讯作者：
Davidson, JRT
影响因子：
17.7
作者：
Kilpatrick, Dean G.;Koenen, Karestan C.;Gelernter, Joel
通讯作者：
Gelernter, Joel
影响因子：
2.4
作者：
Belanger, Heather G.;Uomoto, Jay M.;Vanderploeg, Rodney D.
通讯作者：
Vanderploeg, Rodney D.
DOI：
10.1098/rspb.2008.1788
发表时间：
2009-05-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Fox E;Ridgewell A;Ashwin C
通讯作者：
Ashwin C