Genetic associations with performance on a behavioral measure of distress intolerance.
Genetic associations with performance on a behavioral measure of distress intolerance.
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DOI：
10.1016/j.jpsychires.2011.09.017
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发表时间：
2012-01
影响因子：
4.8
通讯作者：
Lejuez CW
中科院分区：
文献类型：
--
作者：
Amstadter AB;Daughters SB;Macpherson L;Reynolds EK;Danielson CK;Wang F;Potenza MN;Gelernter J;Lejuez CW
理论和经验证据都支持两种候选遗传多态性（SLC 6A 4 5-HTTLPR 1/s和COMT Val 158 Met-rs 4680变体）与情绪调节困难之间的可能关联。一种特殊形式的情绪调节困难，痛苦不容忍，已被测量使用的行为评估在青年;数据表明与不良的心理功能的关系。以前没有研究调查过遗传对青少年情绪调节困难的影响。作为一项关于青少年危险行为的大型纵向研究的一部分，来自大都市华盛顿，华盛顿特区的218名10-14岁的青少年，该地区完成了一项对痛苦耐受力的测量，即对痛苦的弹性行为指标（BIRD），并提供了唾液样本用于DNA提取和基因分型。结果表明，那些具有一个或两个拷贝的5-HTTLPR多态性s等位基因的人更有可能在任务中表现不佳（即，选择退出）比那些纯合子的L等位基因。与Met纯合子相比，COMT Val 158 Met多态性的瓦尔等位基因携带者也更有可能退出任务。一个总结性的风险等位基因得分被创建来联合收割机两种多态性，每个风险等位基因与1.75倍的退出任务的可能性增加相关。探索性分析显示，情感虐待调节5-HTTLPR和BIRD表现之间的关系，以及遗传风险等位基因和BIRD。这是第一次调查的遗传预测的行为措施的容忍痛苦。结果表明，痛苦耐受性至少部分受特定遗传变异的调节。的影响进行了讨论。
Both theory and empirical evidence support possible associations between two candidate genetic polymorphisms (SLC6A4 5-HTTLPR l/s and COMT Val158Met – rs4680 variants) and emotion-regulation difficulties. One particular form of emotion-regulation difficulty, distress intolerance, has been measured using a behavioral assessment in youth; data indicate a relationship with poor psychological functioning. No prior study has investigated genetic influences on emotion-regulation difficulties in youth. As part of a larger longitudinal study on adolescent risk behaviors, 218 10-14 year-old youths from the metropolitan Washington, D.C., area completed a measure of distress intolerance, the Behavioral Indicator of Resilience to Distress (BIRD), and provided saliva samples for DNA extraction and genotyping. Results indicate that those with one or two copies of the s allele of the 5-HTTLPR polymorphism were more likely to perform poorly on the task (i.e., choose to quit) than were those homozygous for the l allele. Participants who were Val allele carriers of the COMT Val158Met polymorphism were also more likely to quit the task compared to Met homozygotes. A summative risk allele score was created to combine the two polymorphisms, and each risk allele was associated with a 1.75 fold increased likelihood of quitting the task. Exploratory analyses revealed that emotional abuse moderated the relationship between the 5-HTTLPR and BIRD performance, as well as the genetic risk allele and the BIRD. This is the first investigation of genetic predictors of a behavioral measure of tolerance to distress. Results suggest that distress tolerance is at least partially regulated by specific genetic variants. Implications are discussed.
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影响因子：
3.5
作者：
Diatchenko, L;Slade, GD;Maixner, W
通讯作者：
Maixner, W
DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
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影响因子：
5.7
作者：
Coman, Ioana L.;Gnirke, Matthew H.;Middleton, Frank A.;Antshel, Kevin M.;Fremont, Wanda;Higgins, Anne Marie;Shprintzen, Robert J.;Kates, Wendy R.
通讯作者：
Kates, Wendy R.
影响因子：
5
作者：
Hashimoto, S;Inoue, T;Koyama, T
通讯作者：
Koyama, T
DOI：
10.1017/s146114570400416x
发表时间：
2004-06-01
影响因子：
4.8
作者：
Domschke, K;Freitag, CM;Deckert, J
通讯作者：
Deckert, J