Alterations in Pulse Pressure Affect Artery Function.
Alterations in Pulse Pressure Affect Artery Function.
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DOI：
10.1007/s12195-012-0251-x
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发表时间：
2012-12-01
影响因子：
2.8
通讯作者：
Han, Hai-Chao
中科院分区：
文献类型：
--
作者：
Hayman, Danika M.;Xiao, Yangming;Yao, Qingping;Jiang, Zonglai;Lindsey, Merry L.;Han, Hai-Chao
关键词：
脉压随心血管疾病和干预措施的变化而变化，但其对血管壁结构和功能的影响却知之甚少。我们研究了脉压升高或降低对动脉功能、细胞功能和细胞外基质重塑的影响。猪颈动脉在无搏动(100 Mm Hg)、搏动(70~130 mm Hg)和超脉动(50~150 mm Hg)条件下培养1~3d。检测血管舒缩反应、壁通透性、细胞增殖、细胞凋亡、细胞外基质重塑和参与动脉粥样硬化形成的蛋白质。我们的结果显示，三天后，高脉动压降低了动脉对硝普钠的反应、基础张力和室壁通透性。非脉动压力可促进细胞增殖。无论是脉动压力还是非脉动压力，都不会引起细胞外基质的改变，也不会改变基质金属蛋白酶-2、基质金属蛋白酶-9、小窝蛋白-1或α-肌动蛋白的表达。超脉动压增加单核细胞趋化蛋白-1基因表达。综上所述，这些变化表明脉压在应用后立即对动脉的影响有限。具体地说，脉压的增加改变了动脉张力和壁通透性，而脉压的降低改变了细胞的增殖。总体而言，这些结果提供了对动脉最初如何对脉压变化做出反应的洞察。
Pulse pressure changes in response to cardiovascular diseases and interventions, but its effect on vascular wall structure and function is poorly understood. We examined the effect of increased or decreased pulse pressure on artery function, cellular function, and extracellular matrix remodeling. Porcine carotid arteries were cultured under non-pulsatile (100 mmHg), pulsatile (70-130 mmHg), or hyper-pulsatile pressure (50-150 mmHg) for 1 to 3 days. Vasomotor response, wall permeability, cell proliferation, apoptosis, extracellular matrix remodeling, and proteins involved in atherogenesis were examined. Our results showed that hyper-pulsatile pressure decreased the artery response to sodium nitroprusside, basal tone, and wall permeability after three days. Non-pulsatile pressure increased cell proliferation. Neither hyper-pulsatile nor non-pulsatile pressure caused a change in the extracellular matrix or in the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, caveolin-1, or α-actin. Hyper-pulsatile pressure increased monocyte chemotactic protein-1 gene expression. Taken together, these changes indicate that pulse pressure has a limited effect on the artery immediately after its application. Specifically an increase in pulse pressure alters the artery tone and wall permeability while a decrease in pulse pressure alters cell proliferation. Overall these results provide insight into how the artery initially responds to changes in pulse pressure.
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发表时间：
2005-08-01
影响因子：
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