Conserved repressive function of Krüppel homolog 1 on insect metamorphosis in hemimetabolous and holometabolous species.
Conserved repressive function of Krüppel homolog 1 on insect metamorphosis in hemimetabolous and holometabolous species.
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DOI：
10.1038/srep00163
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发表时间：
2011
影响因子：
4.6
通讯作者：
Belles, Xavier
中科院分区：
文献类型：
--
作者：
Lozano, Jesus;Belles, Xavier
昆虫的变态是由诱导蜕皮的蜕皮激素和抑制变态变化的幼体激素（JH）调控的。蜕皮甾体的分子作用已被深入研究，但对JH的分子作用了解甚少，目前仅有全代谢物种的数据，如黑腹果蝇（Drosophila melanogaster）和castaneum。我们研究了kr<s:1> ppel同源物1 （Kr-h1）在半代谢模型德国小蠊中的功能。Kr-h1是一种锌指转录因子，其作为JH抗变质作用的转导因子的功能最近在黑胃和castaneum中得到证实。本文报道的RNAi实验表明，Kr-h1在德国小蠊中也能传导JH的抗变质作用，从而表明这种作用是一种祖先条件，在昆虫从半代谢物种进化到全代谢物种的过程中被保存下来。
Insect metamorphosis is regulated by ecdysteroids, which induce molts, and juvenile hormone (JH), which inhibits metamorphic changes. The molecular action of ecdysteroids has been thoroughly studied, but that of JH is poorly understood, with data currently only being available for holometabolous species, like Drosophila melanogaster and Tribolium castaneum. We studied the function of Krüppel homolog 1 (Kr-h1) in Blattella germanica, a hemimetabolous model. Kr-h1 is a Zn finger transcription factor whose function as transductor of the antimetamorphic action of JH has recently been demonstrated in D. melanogaster and T. castaneum. The RNAi experiments reported herein indicated that Kr-h1 transduces the antimetamorphic action of JH also in B. germanica, thereby suggesting that this role is an ancestral condition that has been conserved in insect evolution from hemimetabolous to holometabolous species.
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影响因子：
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通讯作者：
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