Central and Peripheral Clock Control of Circadian Feeding Rhythms.
Central and Peripheral Clock Control of Circadian Feeding Rhythms.
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DOI：
10.1177/07487304211045835
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发表时间：
2021-12
影响因子：
3.5
通讯作者：
Cavanaugh, Daniel J.
中科院分区：
文献类型：
--
作者：
Fulgham, Carson, V;Dreyer, Austin P.;Nasseri, Anita;Miller, Asia N.;Love, Jacob;Martin, Madison M.;Jabr, Daniel A.;Saurabh, Sumit;Cavanaugh, Daniel J.
许多行为在内源性昼夜节律计时系统的控制下表现出约24小时的振荡，该系统通过分子昼夜节律钟跟踪一天中的时间。在果蝇（Drosophila melanogaster）中，大多数昼夜节律研究都集中在运动活动节律的产生上，但一个根本问题是昼夜节律钟如何协调多种不同的行为输出。在这里，我们已经调查了细胞和电路介导的昼夜节律控制的摄食行为。使用一系列的遗传工具，我们表明，是自发活动的节奏的情况下，存在的进食节奏需要在中央大脑的腹外侧时钟神经元的分子时钟功能。我们进一步证明，在这些神经元的分子时钟振荡的速度决定了自由运行的周期长度的喂养节奏。与中央时钟细胞操作观察到的效果相反，我们表明，遗传废除的分子时钟在脂肪体，外周代谢组织，是没有影响的摄食行为。有趣的是，我们发现，在自由奔跑的条件下，控制果蝇的大脑和脂肪体中的分子钟逐渐与彼此异相生长，这可能是由于脂肪生物钟的内源性周期较长。在这些条件下，摄食节律的周期与中央脑时钟细胞中的分子振荡相一致，这与脑时钟在决定摄食行为的时间方面的主要作用一致。最后，尽管缺乏脂肪体选择性操纵的影响，我们发现，苍蝇与同时中断的分子时钟在多个外周组织（但与完整的中央时钟）表现出降低进食节奏强度和减少整体食物摄入量。我们的结论是，中央和外围时钟有助于调节摄食节律，特别是占主导地位，起搏器的作用，为特定群体的中央脑时钟细胞。
Many behaviors exhibit ~24 hr oscillations under control of an endogenous circadian timing system that tracks time of day via a molecular circadian clock. In the fruit fly, Drosophila melanogaster, most circadian research has focused on the generation of locomotor activity rhythms, but a fundamental question is how the circadian clock orchestrates multiple distinct behavioral outputs. Here, we have investigated the cells and circuits mediating circadian control of feeding behavior. Using an array of genetic tools, we show that, as is the case for locomotor activity rhythms, the presence of feeding rhythms requires molecular clock function in the ventrolateral clock neurons of the central brain. We further demonstrate that the speed of molecular clock oscillations in these neurons dictates the free-running period length of feeding rhythms. In contrast to the effects observed with central clock cell manipulations, we show that genetic abrogation of the molecular clock in the fat body, a peripheral metabolic tissue, is without effect on feeding behavior. Interestingly, we find that molecular clocks in the brain and fat body of control flies gradually grow out of phase with one another under free-running conditions, likely due to a long endogenous period of the fat body clock. Under these conditions, the period of feeding rhythms tracks with molecular oscillations in central brain clock cells, consistent with a primary role of the brain clock in dictating the timing of feeding behavior. Finally, despite a lack of effect of fat body selective manipulations, we find that flies with simultaneous disruption of molecular clocks in multiple peripheral tissues (but with intact central clocks) exhibit decreased feeding rhythm strength and reduced overall food intake. We conclude that both central and peripheral clocks contribute to the regulation of feeding rhythms, with a particularly dominant, pacemaker role for specific populations of central brain clock cells.
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DOI：
10.1073/pnas.0702726104
发表时间：
2007-05-15
影响因子：
11.1
作者：
Ja, William W.;Carvalho, Gil B.;Benzer, Seymour
通讯作者：
Benzer, Seymour
影响因子：
64.5
作者：
Asahina K;Watanabe K;Duistermars BJ;Hoopfer E;González CR;Eyjólfsdóttir EA;Perona P;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
10.5
作者：
Dauwalder, B;Tsujimoto, S;Mattox, W
通讯作者：
Mattox, W
影响因子：
56.9
作者：
Delanoue, Renald;Meschi, Eleonora;Leopold, Pierre
通讯作者：
Leopold, Pierre
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS