A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch.
A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch.
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DOI：
10.1016/j.neuroimage.2011.10.099
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发表时间：
2012-02-15
期刊：
影响因子：
5.7
通讯作者：
Yosipovitch G
中科院分区：
文献类型：
--
作者：
Papoiu AD;Coghill RC;Kraft RA;Wang H;Yosipovitch G
之前针对处理瘙痒感的神经网络的 PET 和功能磁共振成像脑成像研究以前使用组胺作为唯一的瘙痒诱导剂。与组胺相反，牛引起的瘙痒是通过蛋白酶激活的受体 PAR2 介导的，并通过单独的脊髓丘脑途径传播，因此对牛引起的大脑激活进行成像可以提供进一步了解瘙痒的中枢处理过程。我们首次报道了功能性 MRI 动脉自旋标记 (ASL) 研究，与组胺引起的瘙痒相比，对牛引起的瘙痒的神经元处理进行了分析。我们还探索了组胺和牛皮紧密结合所引起的大脑反应。我们对 15 名健康志愿者进行的分析结果表明，牛肉和组胺共同激活了一组核心的大脑结构，同时也揭示了显着的差异。两种刺激激活的核心区域存在于丘脑、初级和次级体感皮质、后顶叶皮质、上颞叶皮质和中颞叶皮质、PCC、ACC、楔前叶和楔叶。牛诱导岛叶皮质、屏状核、基底神经节、壳核、丘脑核和枕丘明显明显且更广泛的受累。研究了这两种瘙痒方式之间观察到的差异，以确定定量与定性因素的影响，并探讨了瘙痒强度与大脑激活模式之间的相关性。我们的分析表明，牛皮癣和组胺痒之间最显着的差异不受刺激强度的影响，尽管一部分区域显示出强度依赖性的激活。牛和组胺的联合应用突出了岛叶和屏状核在同时处理两种瘙痒方式中的作用。目前的结果表明，存在重叠但又不同的神经元网络来处理这两种不同类型的瘙痒。
Previous PET and fMRI brain imaging studies targeting neural networks processing itch sensation have previously used histamine as the sole itch inducer. In contrast with histamine, cowhage-induced itch is mediated via proteinase activated receptors PAR2 and is transmitted through a separate spinothalamic pathway, therefore imaging the brain activation evoked by cowhage could provide further insight central processing of itch. We report for the first time a functional MRI Arterial Spin Labeling (ASL) study of neuronal processing of itch induced by cowhage analyzed in contrast with histamine-induced itch. We also explored the brain responses induced by histamine and cowhage combined in a tight sequence. The results of our analyses obtained in a group of 15 healthy volunteers suggested that cowhage and histamine co-activated a core group of brain structures, while also revealed notable differences. Core areas activated by both stimuli were found in the thalamus, primary and secondary somatosensory cortices, posterior parietal cortex, superior and middle temporal cortices, PCC, ACC, precuneus and cuneus. Cowhage induced a notably distinct and more extensive involvement of the insular cortex, claustrum, basal ganglia, putamen, thalamic nuclei and pulvinar. The differences observed between these two itch modalities were investigated to determine the impact of quantitative versus qualitative factors, and correlations between itch intensity and the patterns in brain activation were explored. Our analysis revealed that the most significant differences between cowhage and histamine itch were not affected by stimulus intensity, although a subset of regions displayed activations which were intensity-dependent. The combined application of cowhage and histamine highlighted the role of insula and claustrum in the processing of both itch modalities in the same time. The present results suggest the existence of overlapping but also distinct neuronal networks processing these two different types of itch.
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影响因子：
5.3
作者：
Davidson, Steve;Zhang, Xijing;Giesler, Glenn J., Jr.
通讯作者：
Giesler, Glenn J., Jr.
影响因子：
3.1
作者：
Menon, Vinod;Uddin, Lucina Q.
通讯作者：
Uddin, Lucina Q.
影响因子：
3.7
作者：
Papoiu AD;Tey HL;Coghill RC;Wang H;Yosipovitch G
通讯作者：
Yosipovitch G
影响因子：
7.4
作者：
Owen, D. G.;Bureau, Y.;Lawrence, K. S. St.
通讯作者：
Lawrence, K. S. St.
影响因子：
2.5
作者：
Mochizuki, Hideki;Inui, Koji;Kakigi, Ryusuke
通讯作者：
Kakigi, Ryusuke