Bioprinted Hydrogels for Fibrosis and Wound Healing: Treatment and Modeling.
Bioprinted Hydrogels for Fibrosis and Wound Healing: Treatment and Modeling.
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DOI：
10.3390/gels9010019
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发表时间：
2022-12-27
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影响因子：
--
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三维（3D）打印已被用于制造具有精细控制的物理结构和自定义的生物配体图案的生物材料支架。令人兴奋的是，生物打印技术的最新进展使高度仿生水凝胶的发展成为可能，用于治疗纤维化和促进伤口愈合。生物打印水凝胶提供了更准确的生物化学和生物物理线索的空间再现，从而抑制纤维化和促进组织再生，增强了基于水凝胶的治疗潜力。因此，生物打印水凝胶已被用于多种组织和器官的纤维化治疗，包括皮肤、心脏和子宫内膜。此外，生物打印水凝胶已被用于急性和慢性伤口的愈合，这些伤口呈现出独特的生物微环境。除了这些治疗应用之外，水凝胶生物打印还被用于在各种软组织（如皮肤、心脏和肝脏）中生成体外纤维化模型，从而以相对较低的成本实现高通量药物筛选和组织分析。随着生物学研究开始揭示纤维化和伤口愈合背后的空间生物学特征，生物打印为一系列转化应用提供了一个强大的工具包，可以概括空间上定义的促再生和抗纤维化线索。
Three-dimensional (3D) printing has been used to fabricate biomaterial scaffolds with finely controlled physical architecture and user-defined patterning of biological ligands. Excitingly, recent advances in bioprinting have enabled the development of highly biomimetic hydrogels for the treatment of fibrosis and the promotion of wound healing. Bioprinted hydrogels offer more accurate spatial recapitulation of the biochemical and biophysical cues that inhibit fibrosis and promote tissue regeneration, augmenting the therapeutic potential of hydrogel-based therapies. Accordingly, bioprinted hydrogels have been used for the treatment of fibrosis in a diverse array of tissues and organs, including the skin, heart, and endometrium. Furthermore, bioprinted hydrogels have been utilized for the healing of both acute and chronic wounds, which present unique biological microenvironments. In addition to these therapeutic applications, hydrogel bioprinting has been used to generate in vitro models of fibrosis in a variety of soft tissues such as the skin, heart, and liver, enabling high-throughput drug screening and tissue analysis at relatively low cost. As biological research begins to uncover the spatial biological features that underlie fibrosis and wound healing, bioprinting offers a powerful toolkit to recapitulate spatially defined pro-regenerative and anti-fibrotic cues for an array of translational applications.
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影响因子：
13.6
作者：
Hinton TJ;Jallerat Q;Palchesko RN;Park JH;Grodzicki MS;Shue HJ;Ramadan MH;Hudson AR;Feinberg AW
通讯作者：
Feinberg AW
影响因子：
4.1
作者：
Feng M;Hu S;Qin W;Tang Y;Guo R;Han L
通讯作者：
Han L
影响因子：
18.9
作者：
Guan G;Huo D;Li Y;Zhao X;Li Y;Qin Z;Sun D;Yang G;Yang M;Tan J;Zeng W;Zhu C
通讯作者：
Zhu C
DOI：
10.1126/science.aav9750
发表时间：
2019-05-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Grigoryan B;Paulsen SJ;Corbett DC;Sazer DW;Fortin CL;Zaita AJ;Greenfield PT;Calafat NJ;Gounley JP;Ta AH;Johansson F;Randles A;Rosenkrantz JE;Louis-Rosenberg JD;Galie PA;Stevens KR;Miller JS
通讯作者：
Miller JS
DOI：
10.1016/j.msec.2021.112422
发表时间：
2021-09-15
影响因子：
7.9
作者：
Chen, Zheng;Wu, Hang;Wang, Shige
通讯作者：
Wang, Shige