Simulated two-dimensional red blood cell motion, deformation, and partitioning in microvessel bifurcations.
Simulated two-dimensional red blood cell motion, deformation, and partitioning in microvessel bifurcations.
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DOI：
10.1007/s10439-008-9546-4
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发表时间：
2008-10
影响因子：
3.8
通讯作者：
Secomb, Timothy W.
中科院分区：
文献类型：
--
作者：
Barber, Jared O.;Alberding, Jonathan P.;Restrepo, Juan M.;Secomb, Timothy W.
利用二维柔性粒子模型模拟了哺乳动物红细胞（红细胞）在微血管分叉分叉中的运动、变形和分裂。一组粘弹性元件代表红细胞膜和细胞质。考虑孤立细胞的运动，忽略细胞间的相互作用。质心轨迹偏离背景流线是由于柔性细胞向分叉上游的母血管中心线迁移，以及由于分叉附近的细胞阻塞引起的流动扰动。对于给定的总流量分区和给定的上游红细胞分布，通过确定进入每个分支的红细胞分数来预测分岔中的红细胞分区。通常，红细胞优先进入高流量分支，导致下游分支的放电红细胞比容不均匀。这种效应因向中心线迁移而增强，但因阻塞而减弱。弹性细胞比相应大小的刚性圆形颗粒更强，并且随着母血管直径的增加而降低。对于大小不等的子血管，分配是不对称的，红细胞倾向于进入较小的血管。分区不受分支角度的显著影响。模型预测与以前的实验结果一致。
Movement, deformation, and partitioning of mammalian red blood cells (RBCs) in diverging microvessel bifurcations are simulated using a two-dimensional, flexible-particle model. A set of viscoelastic elements represents the RBC membrane and the cytoplasm. Motion of isolated cells is considered, neglecting cell-to-cell interactions. Center-of-mass trajectories deviate from background flow streamlines due to migration of flexible cells towards the mother vessel centerline upstream of the bifurcation and due to flow perturbations caused by cell obstruction in the neighborhood of the bifurcation. RBC partitioning in the bifurcation is predicted by determining the RBC fraction entering each branch, for a given partition of total flow and for a given upstream distribution of RBCs. Typically, RBCs preferentially enter the higher-flow branch, leading to unequal discharge hematocrits in the downstream branches. This effect is increased by migration toward the centerline but decreased by the effects of obstruction. It is stronger for flexible cells than for rigid circular particles of corresponding size, and decreases with increasing parent vessel diameter. For unequally-sized daughter vessels, partitioning is asymmetric, with RBCs tending to enter the smaller vessel. Partitioning is not significantly affected by branching angles. Model predictions are consistent with previous experimental results.
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影响因子：
3.8
作者：
El-Kareh, AW;Secomb, TW
通讯作者：
Secomb, TW
DOI：
10.1115/1.2891401
发表时间：
1992-08-01
影响因子：
1.7
作者：
ENDEN, G;POPEL, AS
通讯作者：
POPEL, AS
影响因子：
3.1
作者：
AUDET, DM;OLBRICHT, WL
通讯作者：
OLBRICHT, WL
DOI：
10.1152/ajpheart.00297.2005
发表时间：
2005-12-01
影响因子：
4.8
作者：
Pries, AR;Secomb, TW
通讯作者：
Secomb, TW
影响因子：
3.8
作者：
Secomb, Timothy W.;Styp-Rekowska, Beata;Pries, Axel R.
通讯作者：
Pries, Axel R.