Promising Antifungal Targets Against Candida albicans Based on Ion Homeostasis.
Promising Antifungal Targets Against Candida albicans Based on Ion Homeostasis.
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DOI：
10.3389/fcimb.2018.00286
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发表时间：
2018
影响因子：
5.7
通讯作者：
Sun S
中科院分区：
文献类型：
--
作者：
Li Y;Sun L;Lu C;Gong Y;Li M;Sun S
近几十年来，侵袭性真菌感染显著增加，导致免疫抑制患者的高发病率和死亡率。白色念珠菌（C.白色念珠菌）是人类中最普遍的机会性真菌病原体，其可引起严重且通常致命的血流感染。目前的抗真菌剂有几个局限性，包括只有少数类别的抗真菌剂是可用的，其中某些具有严重的毒性和高成本。此外，耐药性的出现是成功患者结局的新限制。因此，开发具有新靶点的抗真菌药物是有效控制念珠菌的重要策略。白色念珠菌感染人们普遍认为，离子稳态对所有活细胞都至关重要。许多研究表明，离子信号和转导网络通过调节基因表达、形态转变、宿主入侵、应激反应和抗药性而对真菌的生存起着重要作用。离子稳态失调迅速介导细胞死亡，形成越来越多的化合物，引起抗真菌活性的机制基础。大多数强效抗真菌药物已被广泛应用于临床，其中某些药物具有低毒性，这意味着它们有望在未来用作抗真菌药物。因此，我们简要地总结了几个重要的离子，这些离子信号网络的基础上潜在的抗真菌靶点，和抗真菌化合物的离子稳态破坏的基础上的稳态调节。这一总结将有助于设计有效的药物，并确定新的目标，打击真菌疾病。
In recent decades, invasive fungal infections have been increasing significantly, contributing to high incidences and mortality in immunosuppressed patients. Candida albicans (C. albicans) is the most prevalent opportunistic fungal pathogen in humans that can cause severe and often fatal bloodstream infections. Current antifungal agents have several limitations, including that only a small number of classes of antifungals are available, certain of which have severe toxicity and high cost. Moreover, the emergence of drug resistance is a new limitation to successful patient outcomes. Therefore, the development of antifungals with novel targets is an essential strategy for the efficient management of C. albicans infections. It is widely recognized that ion homeostasis is crucial for all living cells. Many studies have identified that ion-signaling and transduction networks are central to fungal survival by regulating gene expression, morphological transition, host invasion, stress response, and drug resistance. Dysregulation of ion homeostasis rapidly mediates cell death, forming the mechanistic basis of a growing number of compounds that elicit antifungal activity. Most of the potent antifungals have been widely used in the clinic, and certain of them have low toxicity, meaning that they may be expected to be used as antifungal drugs in the future. Hence, we briefly summarize the homeostasis regulation of several important ions, potential antifungal targets based on these ion-signaling networks, and antifungal compounds based on the disruption of ion homeostasis. This summary will help in designing effective drugs and identifying new targets for combating fungal diseases.
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影响因子：
11.3
作者：
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影响因子：
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