Polyaniline nanoparticles: potential optical coherence tomography contrast agents
Polyaniline nanoparticles: potential optical coherence tomography contrast agents
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聚苯胺纳米粒子：潜在的光学相干断层扫描造影剂
DOI：
10.1364/jot.82.000639
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发表时间：
2015-09
影响因子：
0.4
通讯作者：
Zhouyi
中科院分区：
文献类型：
--
作者：
Yu;Jianfeng;Liu;Zhiming;Wang;Xinpeng;Jin;Mei;Chen;Haolin;Guo;Zhouyi
聚苯胺是一种有机导电聚合物，在近红外区域表现出强的光吸收。在此，研究了聚苯胺纳米粒子作为光学相干断层扫描成像造影剂的潜力。通过简单的化学氧化方法合成了聚苯胺纳米粒子。从离体猪肝组织获得的光学相干断层扫描图像显示了聚苯胺纳米颗粒的浓度依赖性对比效果。然后，使用异种移植肿瘤小鼠模型将纳米制剂应用于肿瘤组织的体内光学相干断层扫描成像。注射聚苯胺纳米粒子的肿瘤的光学相干断层扫描信号的穿透深度显着低于注射磷酸盐缓冲溶液的肿瘤。然后通过光学相干断层扫描信号的衰减系数定量研究聚苯胺纳米粒子的显着对比效果。此外，还通过拉曼光谱研究了聚苯胺纳米颗粒在组织中的渗透动力学。
Polyaniline, an organic conducting polymer, exhibits strong light absorption in the near-infrared region. Herein, the potential of polyaniline nanoparticles as the contrast agents for optical coherence tomography imaging was investigated. Polyaniline nanoparticles were synthesized by a facile chemical oxidative method. The optical coherence tomography images obtained from ex vivo swine liver tissues showed the concentration-dependent contrast effect of polyaniline nanoparticles. Then the nanoagents were applied to in vivo optical coherence tomography imaging of tumor tissues using a xenograft tumor mouse model. The penetration depth of the optical coherence tomography signals from tumors injected with polyaniline nanoparticles was significantly lower than that from tumors injected with phosphate buffer solution. The remarkable contrast effect of polyaniline nanoparticles was then quantitatively studied by the attenuation coefficients of optical coherence tomography signals. Furthermore, the permeation dynamics of polyaniline nanoparticles in tissue was also studied by Raman spectroscopy.
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影响因子：
3.9
作者：
Jianghua Li;Bingling Chen;Yong Du;Lifeng Yang;Yun-Fei Xia;Yonghong He;Song-hao Liu;Changshui Chen
通讯作者：
Jianghua Li;Bingling Chen;Yong Du;Lifeng Yang;Yun-Fei Xia;Yonghong He;Song-hao Liu;Changshui Chen
影响因子：
3.3
作者：
Tong L;Wei Q;Wei A;Cheng JX
通讯作者：
Cheng JX
影响因子：
3.5
作者：
Park, BH;Saxer, C;de Boer, JF
通讯作者：
de Boer, JF
聚苯胺/MoO3杂化材料的合成、电化学及气敏性能
影响因子：
2.5
作者：
Wei, Xin;Jiao, Lifang;Yuan, Huatang
通讯作者：
Yuan, Huatang
DOI：
10.1016/s1296-2147(01)01257-4
发表时间：
2001-10-01
期刊：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE IV PHYSIQUE ASTROPHYSIQUE
影响因子：
--
作者：
Fujimoto, JG
通讯作者：
Fujimoto, JG