Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects.
Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects.
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DOI：
10.1111/j.1751-1097.2008.00507.x
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发表时间：
2009-01
影响因子：
3.3
通讯作者：
Cheng JX
中科院分区：
文献类型：
--
作者：
Tong L;Wei Q;Wei A;Cheng JX
金纳米棒（NR）在近红外（NIR）区域具有等离子体共振吸收和散射，使其成为体外和体内成像的有吸引力的探针。在细胞环境中，NR可以为暗场显微镜提供散射对比，或者由于等离子体增强的双光子吸收而发射强的双光子发光（TPL）。NR也已经用于生物医学成像模态，诸如光学相干断层扫描（OCT）或光声断层扫描（PAT）。对表面化学的仔细控制通过实现细胞特异性靶向以及通过增加其分散稳定性和循环寿命来增强NR作为生物成像剂的能力。NR还可以有效地将光能转化为热量，并对肿瘤细胞造成局部损伤。NR的激光诱导加热可以破坏细胞膜的完整性和稳态，导致Ca2+内流和细胞内肌动蛋白网络的解聚。等离子体共振光学性质，强烈的局部光热效应，和强大的表面化学的组合，使金NR作为有前途的治疗剂。
Gold nanorods (NRs) have plasmon-resonant absorption and scattering in the near-infrared (NIR) region, making them attractive probes for in vitro and in vivo imaging. In the cellular environment, NRs can provide scattering contrast for darkfield microscopy, or emit a strong two-photon luminescence (TPL) due to plasmon-enhanced two-photon absorption. NRs have also been employed in biomedical imaging modalities such as optical coherence tomography (OCT) or photoacoustic tomography (PAT). Careful control over surface chemistry enhances the capacity of NRs as biological imaging agents by enabling cell-specific targeting, and by increasing their dispersion stability and circulation lifetimes. NRs can also efficiently convert optical energy into heat, and inflict localized damage to tumor cells. Laser-induced heating of NRs can disrupt cell membrane integrity and homeostasis, resulting in Ca2+ influx and the depolymerization of the intracellular actin network. The combination of plasmon-resonant optical properties, intense local photothermal effects, and robust surface chemistry render gold NRs as promising theragnostic agents.
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