Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults.
Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults.
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骨髓肥胖以及内脏和皮下脂肪对年轻健康成年人心血管风险的不同影响。
DOI：
10.1038/ijo.2008.170
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发表时间：
2008-12
影响因子：
4.9
通讯作者：
Gilsanz, V.
中科院分区：
文献类型：
--
作者：
Di Iorgi, N.;Mittelman, S. D.;Gilsanz, V.
Adipose tissue is an endocrine organ that influences many metabolic processes and accumulates in different depots, including the bone marrow. While the negative associations between visceral fat (VF) or subcutaneous fat (SF) and cardiovascular disease (CVD) risks are well known, the relation between marrow fat (MF) and metabolic risk is unexplored. We examined the relations between these three fat depots and whether CVD risks are associated to marrow adiposity. observational cross sectional study Computed tomography was used to measure VF, SF and MF depots in 131 healthy young adults (60 females, 71 males; 16-25 years of age). Weight, body mass index (BMI), waist and hip circumferences, blood pressure (BP), carotid intima media thickness (CIMT) and serum levels of lipids, glucose and insulin were also measured. Regardless of gender, MF was not associated to values of VF or SF, anthropometric measures, or lipid or carbohydrate serum levels (P >0.05 for all). In contrast, VF was associated to SF (r’s= 0.74 for females, 0.78 for males; both P’s <0.0001) and these depots were related to anthropometric parameters (r’s between .69 and .87; all P’s <0.0001) and to most measures of lipids, glucose or insulin (r’s between .25 and .62). Marrow adiposity in young men and women is independent of visceral and subcutaneous fat, and is not associated to CVD risk. These findings do not support the concept that marrow adiposity is involved in the comorbidities related to fat accumulation in other compartments.
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影响因子：
7.1
作者：
Caprio, S;Hyman, LD;Tamborlane, WV
通讯作者：
Tamborlane, WV
影响因子：
19.7
作者：
Gonzalez, Jaime;Wood, John C.;Gilsanz, Vicente
通讯作者：
Gilsanz, Vicente
影响因子：
7.7
作者：
Gower, BA;Nagy, TR;Goran, MI
通讯作者：
Goran, MI
影响因子：
4.4
作者：
Klaus, S;Keijer, J
通讯作者：
Keijer, J
影响因子：
4.5
作者：
Justesen, J;Stenderup, K;Kassem, M
通讯作者：
Kassem, M