Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Vaccination Strategies Based on NK Cell and ILC Memory.
Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Vaccination Strategies Based on NK Cell and ILC Memory.
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DOI：
10.1101/cshperspect.a029512
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发表时间：
2018-10-01
影响因子：
7.2
通讯作者：
Colonna M
中科院分区：
文献类型：
--
作者：
Cooper MA;Fehniger TA;Colonna M
过去十年的研究已经明确地表明，天然免疫自然杀伤(NK)细胞在单一激活事件后表现出增强的长期功能反应。随着人们对NK细胞的记忆和类似记忆特性的认识增加，人们开始质疑它们是否有能力有效地调节人类的疫苗接种反应。此外，最近发现的先天性淋巴样细胞(ILC)也可能具有记忆样功能。在这里，我们回顾了不同形式的NK细胞记忆，并推测这些细胞和ILC对疫苗反应有意义的贡献的能力。
Studies over the last decade have decisively demonstrated that innate immune natural killer (NK) cells exhibit enhanced long-lasting functional responses following a single activation event. With the increased recognition of memory and memory-like properties of NK cells, questions have arisen with regards to their ability to effectively mediate vaccination responses in humans. Moreover, recently discovered innate lymphoid cells (ILC) could also potentially exhibit memory-like functions. Here we review different forms of NK cell memory, and speculate about the ability of these cells and ILCs to meaningfully contribute to vaccination responses.
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影响因子：
32.4
作者：
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