Pregnancy intention and phthalate metabolites among pregnant women in The Infant Development and Environment Study cohort.
Pregnancy intention and phthalate metabolites among pregnant women in The Infant Development and Environment Study cohort.
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DOI：
10.1111/ppe.12674
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发表时间：
2020-11
影响因子：
2.8
通讯作者：
Nguyen RHN
中科院分区：
文献类型：
--
作者：
Lyden GR;Barrett ES;Sathyanarayana S;Bush NR;Swan SH;Nguyen RHN
孕前生活方式和健康对怀孕健康有积极影响，这包括减少接触干扰内分泌的化学物质，如邻苯二甲酸盐。我们之前已经证明，计划使用辅助生殖技术（ART）怀孕的妇女的邻苯二甲酸盐代谢物浓度低于未使用ART的妇女。为了确定有意怀孕的妇女是否比意外怀孕的妇女有更低的邻苯二甲酸盐代谢物浓度，或者在怀孕期间两组之间邻苯二甲酸盐暴露的变化是否不同。721名妇女参加了婴儿发育与环境研究（TIDES），这是一项多中心的美国前瞻性妊娠队列研究；513名（71%）表示她们的怀孕是有计划的。从孕早期和晚期就诊的尿液样本进行了10个比重调整，自然对数转化邻苯二甲酸酯代谢物的分析。采用简单和多变量线性回归，调整中心、种族、年龄、收入、婚姻状况和胎次，以确定邻苯二甲酸酯代谢物浓度是否因怀孕意向而不同。在双变量分析中，所有妊娠早期和大多数妊娠晚期邻苯二甲酸盐的几何平均浓度在计划外怀孕的妇女中较高。然而，在协变量调整后，只有孕早期邻苯二甲酸单异丁酯（MiBP）仍与妊娠意图相关，并且这种关联改变了方向，使得计划外妊娠的MiBP浓度较低（ß - 0.18, 95% CI - 0.35, - 0.02）。我们没有发现怀孕计划者和非计划者在邻苯二甲酸盐暴露方面存在差异的证据。
Preconception lifestyle and health play a pivotal role in positively impacting the health of a pregnancy, and this includes the reduction of exposure to endocrine-disrupting chemicals such as phthalates. We have previously demonstrated that women planning a pregnancy with assisted reproductive technology (ART) have lower phthalate metabolite concentrations than their non-ART-using counterparts. To determine if women who intended to become pregnant had lower phthalate metabolite concentrations than those who had an unintended pregnancy, or if change in phthalate exposure across pregnancy differed between these two groups. 721 women enrolled in The Infant Development and Environment Study (TIDES), a multicenter U.S. prospective pregnancy cohort; 513 (71%) indicated their pregnancy was planned. Urine samples from first and third trimester visits were analyzed for 10 specific-gravity-adjusted, natural-log-transformed phthalate metabolites. Simple and multivariable linear regression, adjusting for center, race, age, income, marital status, and parity, were employed to determine whether phthalate metabolite concentrations differed by pregnancy intention. In bivariate analyses, the geometric mean concentrations of all first trimester and most third trimester phthalates were higher in women with unplanned pregnancies. However, after covariate adjustment, only first trimester monoisobutyl phthalate (MiBP) remained associated with pregnancy intention, and the association changed direction such that unplanned pregnancies had lower MiBP concentrations (ß −0.18, 95% CI −0.35, −0.02). We did not find evidence of a difference in phthalate exposure between pregnancy planners and non-planners.
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影响因子：
4.1
作者：
Kasahara, E;Sato, EF;Inoue, M
通讯作者：
Inoue, M
影响因子：
4.5
作者：
Lee, Ena;Ahn, Mee Young;Kim, Hyung Sik
通讯作者：
Kim, Hyung Sik
影响因子：
11.8
作者：
Berger K;Eskenazi B;Balmes J;Holland N;Calafat AM;Harley KG
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Harley KG
DOI：
10.1016/j.jchromb.2007.10.023
发表时间：
2007-12-01
影响因子：
3
作者：
Silva, Manori J.;Samandar, Ella;Calafat, Antonia M.
通讯作者：
Calafat, Antonia M.
影响因子：
6.1
作者：
Swan, S. H.;Sathyanarayana, S.;Redmon, J. B.
通讯作者：
Redmon, J. B.