Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample.
Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample.
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DOI：
10.1016/j.cortex.2012.08.011
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发表时间：
2013-07
期刊：
影响因子：
3.6
通讯作者：
Ressler, Kerry J.
中科院分区：
文献类型：
--
作者：
Jovanovic, Tanja;Ely, Tim;Fani, Negar;Glover, Ebony M.;Gutman, David;Tone, Erin B.;Norrholm, Seth D.;Bradley, Bekh;Ressler, Kerry J.
安全线索对恐惧的抑制作用减弱，恐惧线索的消退能力不足，越来越被认为是创伤后应激障碍(PTSD)的重要生物学标志。其他研究表明，在PTSD受试者的行为抑制任务中，可能存在神经激活的变化。目前的研究旨在了解在高度创伤的平民人群中，抑制过程中的神经激活是否减少，以及非典型激活是否与恐惧抑制受损有关。参与者是从佐治亚州亚特兰大格雷迪纪念医院招募的41名创伤后女性(20名创伤后应激障碍+，21名创伤后应激障碍−)。我们在高分辨率3T扫描仪上使用Go/NoGo程序和功能磁共振成像(FMRI)。参与者被指示在屏幕上出现“X”或“O”时按下按钮，但如果字母后面出现红色方块，则不按下按钮。参与者被评估了创伤病史和创伤后应激障碍的诊断，并完成了增强恐惧的惊吓和灭绝范式。我们发现，在没有创伤后应激障碍的创伤受试者中，没有创伤后应激障碍的受试者的腹内侧额前皮质(VmPFC)比那些有创伤后应激障碍的受试者在NoGo比Go对照条件下有更强的激活。VmPFC的激活与安全信号学习期间恐惧增强的惊吓反应(p=.02)和恐惧消退(p=.0002)呈负相关。这些结果有助于理解参与抑制过程的神经回路如何在创伤后应激障碍中存在缺陷。此外，在不同的恐惧条件化和消退过程中，参与行为抑制的相同回路似乎也参与了恐惧抑制过程。
Impaired inhibition of fear in the presence of safety cues and a deficiency in the extinction of fear cues are increasingly thought to be important biological markers of Posttraumatic Stress Disorder (PTSD). Other studies have suggested that there may be altered neural activation during behavioral inhibition tasks in subjects with PTSD. The current study aimed to see whether neural activation during inhibition was reduced in a highly traumatized civilian population, and whether atypical activation was associated with impaired fear inhibition. The participants were 41 traumatized women (20 PTSD+, 21 PTSD−) recruited from Grady Memorial Hospital in Atlanta, GA. We used a Go/NoGo procedure with functional magnetic resonance imaging (fMRI) in a high-resolution 3T scanner. Participants were instructed to press a button whenever an “X” or “O” appeared on the screen, but not if a red square appeared behind the letter. Participants were assessed for trauma history and PTSD diagnosis, and completed a fear-potentiated startle and extinction paradigm. We found stronger activation in the ventromedial prefrontal cortex (vmPFC) in traumatized subjects without PTSD compared to those with PTSD in the NoGo greater than Go contrast condition. Activation in the vmPFC was negatively correlated with fear-potentiated startle responses during safety signal learning (p=.02) and fear extinction (p=.0002). These results contribute to understanding of how the neural circuitry involved in inhibitory processes may be deficient in PTSD. Furthermore, the same circuits involved in behavioral inhibition appear to be involved in fear inhibition processes during differential fear conditioning and extinction.
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