Mesenchymal stem cells in hematopoietic stem cell transplantation.
Mesenchymal stem cells in hematopoietic stem cell transplantation.
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DOI：
10.1080/14653240903193806
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发表时间：
2009
期刊：
影响因子：
4.5
通讯作者：
Hematti P
中科院分区：
文献类型：
--
作者：
Battiwalla M;Hematti P
骨髓（BM）来源的间充质基质/干细胞（MSCs）不仅为造血干细胞（hsc）提供支持性微环境，而且还能够分化为各种间充质来源的细胞类型，如骨、脂肪和软骨。体外和体内数据表明，间充质干细胞具有较低的固有免疫原性，通过与免疫细胞的相互作用调节/抑制免疫反应，并通过其多样化的生物学特性使受损组织参与再生过程。BM衍生的间充质干细胞正在广泛的临床应用中进行评估，包括各种疾病，如心肌梗死或新诊断的1型糖尿病。然而，它们在造血干细胞移植中的应用，无论是用于增强造血植入还是用于治疗/预防移植物抗宿主病，都远远领先于其他适应症。MSCs易于分离和体外扩增，结合其有趣的免疫调节特性，以及在各种临床试验中令人印象深刻的安全性记录，使这些细胞成为进一步研究的有希望的候选者。
Mesenchymal stromal/stem cells (MSCs) of bone marrow (BM) origin not only provide the supportive microenvironmental niche for hematopoietic stem cells (HSCs) but are also capable of differentiating into various cell types of mesenchymal origin, such as bone, fat, and cartilage. In vitro and in vivo data suggest that MSCs have low inherent immunogenicity, modulate/suppress immunological responses through interactions with immune cells, and home to damaged tissues to participate in regeneration processes through their diverse biological properties. MSCs derived from BM are being evaluated for a wide range of clinical applications including disorders as diverse as myocardial infarction or newly diagnosed diabetes mellitus type-1. However, their use in HSC transplantation, either for enhancement of hematopoietic engraftment or for treatment/prevention of graft versus host disease, is far ahead of other indications. Ease of isolation and ex vivo expansion of MSCs, combined with their intriguing immunomodulatory properties, and their impressive record of safety in a wide variety of clinical trials make these cells promising candidates for further investigation.
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