Variable effects of parabrachial nucleus lesions on salt appetite in rats depending upon experimental paradigm and saline concentration.
Variable effects of parabrachial nucleus lesions on salt appetite in rats depending upon experimental paradigm and saline concentration.
复制标题
DOI：
10.1037/a0031716
复制
发表时间：
2013-04
影响因子：
1.9
通讯作者：
Norgren, Ralph
中科院分区：
文献类型：
--
作者：
Stricker, Edward M.;Grigson, Patricia S.;Norgren, Ralph
以往的研究表明，双侧病变的味觉（内侧）区的臂旁核（PBN）在脑桥消除盐食欲诱导的利尿剂，呋塞米治疗大鼠。本研究采用多种盐食欲模型，对鹅膏蕈氨酸致PBN损伤大鼠的NaCl摄入量进行了重新研究。条件性味觉厌恶（PBN损伤的既定后果）的损害被用作初始筛选，以评估病变的有效性。PBN病变的大鼠没有喝0.3 M NaCl或0.5 M NaCl，每天用醋酸脱氧皮质酮治疗。这些结果表明，盐皮质激素介导的盐食欲的兴奋性刺激被PBN病变取消。与此相反，PBN病变的大鼠喝了一些0.5 M的NaCl，和更多的0.3 M的NaCl，除了水的反应引起的低血容量皮下注射30%的聚乙二醇溶液。这些结果表明，兴奋性刺激盐食欲，可能是由血管紧张素II介导的，并没有被废除PBN病变。这些和其他观察结果表明，大鼠味觉PBN的病变可能会或可能不会消除盐的食欲，这取决于使用哪种模型和哪种浓度的NaCl溶液是可用的。
Previous studies have demonstrated that bilateral lesions of the gustatory (medial) zone of the parabrachial nucleus (PBN) in the pons eliminate the salt appetite induced in rats by treatment with the diuretic drug, furosemide. The present studies re-examined NaCl intake of rats with PBN lesions induced by ibotenic acid, using multiple models of salt appetite. The impairment of a conditioned taste aversion, an established consequence of PBN damage, was used as an initial screen with which to assess the effectiveness of the lesions. Rats with PBN lesions did not drink either 0.3 M NaCl or 0.5 M NaCl in response to daily treatment with desoxycorticosterone acetate. These findings suggest that the excitatory stimulus of salt appetite mediated by mineralocorticoids is abolished by PBN lesions. In contrast, rats with PBN lesions drank some 0.5 M NaCl, and more 0.3 M NaCl, in addition to water in response to hypovolemia induced by subcutaneous injection of 30% polyethylene glycol solution. Those findings suggest that an excitatory stimulus of salt appetite, presumably mediated by angiotensin II, is not abolished by PBN lesions. These and other observations indicate that lesions of the gustatory PBN in rats may or may not eliminate salt appetite, depending on which model is used and which concentration of NaCl solution is available.
登录
查看更多内容
影响因子：
2.5
作者：
NORGREN, R;LEONARD, CM
通讯作者：
LEONARD, CM
影响因子：
2.9
作者：
Curtis, KS;Verbalis, JG;Stricker, EM
通讯作者：
Stricker, EM
DOI：
10.1016/s0091-6773(74)91914-2
发表时间：
1974-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
JALOWIEC, JE
通讯作者：
JALOWIEC, JE
影响因子：
2.9
作者：
Kimura, Everton Heidi;Oliveira, Lisandra B.;Callera, Joao Carlos
通讯作者：
Callera, Joao Carlos
影响因子：
2.9
作者：
NORGREN, R;PFAFFMANN, C
通讯作者：
PFAFFMANN, C