A novel anti-influenza copper oxide containing respiratory face mask.
A novel anti-influenza copper oxide containing respiratory face mask.
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DOI：
10.1371/journal.pone.0011295
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发表时间：
2010-06-25
期刊：
影响因子：
3.7
通讯作者：
Gabbay J
中科院分区：
文献类型：
--
作者：
Borkow G;Zhou SS;Page T;Gabbay J
防护性呼吸口罩保护佩戴者的鼻子和嘴巴免受携带病毒或其他传染性病原体的蒸汽滴的伤害。然而，不正确的使用和处置实际上可能会增加病原体传播的风险，而不是减少它，特别是当口罩被非专业人员使用时，如普通人。氧化铜显示出强大的抗病毒特性。已经开发出一种平台技术，将氧化铜永久引入聚合物材料中，使其具有强大的生物杀灭性能。我们证明，将氧化铜浸渍到呼吸防护口罩中，除了其固有的过滤特性外，还具有强大的生物杀灭特性。在模拟呼吸条件下，对照组和氧化铜浸渍口罩对人甲型H1N1流感病毒(H1N1)和禽流感病毒(H9N2)的对数10TCID50分别为5.66±0.51和6.17±0.37log10TCID50，滤过率均在99.85%以上(28.3 L/分钟)。重要的是，在30分钟内，含铜口罩(≤0.88log10TCID50)和对照口罩(4.67±1.35log10TCID50)的甲型流感病毒滴度均未恢复。同样，含铜口罩的传染性禽流感滴度为≤0.97±0.01log10TCID50，而对照口罩的滴度为5.03±0.54log10TCID50。含铜口罩通过了符合欧洲EN 14683：2005和NIOSHN95标准的旨在测试口罩过滤性能的合成血液测试，成功地通过了细菌过滤效果、差压、乳胶颗粒挑战和抗渗透性测试。将氧化铜浸渍到呼吸防护口罩中，使其具有强大的抗流感生物杀灭特性，而不会改变其物理屏障特性。使用杀生口罩可以显著降低由于口罩处理和处置不当而造成的手部或环境污染的风险，从而减少后续感染的风险。
Protective respiratory face masks protect the nose and mouth of the wearer from vapor drops carrying viruses or other infectious pathogens. However, incorrect use and disposal may actually increase the risk of pathogen transmission, rather than reduce it, especially when masks are used by non-professionals such as the lay public. Copper oxide displays potent antiviral properties. A platform technology has been developed that permanently introduces copper oxide into polymeric materials, conferring them with potent biocidal properties. We demonstrate that impregnation of copper oxide into respiratory protective face masks endows them with potent biocidal properties in addition to their inherent filtration properties. Both control and copper oxide impregnated masks filtered above 99.85% of aerosolized viruses when challenged with 5.66±0.51 and 6.17±0.37 log10TCID50 of human influenza A virus (H1N1) and avian influenza virus (H9N2), respectively, under simulated breathing conditions (28.3 L/min). Importantly, no infectious human influenza A viral titers were recovered from the copper oxide containing masks within 30 minutes (≤0.88 log10TCID50), while 4.67±1.35 log10TCID50 were recovered from the control masks. Similarly, the infectious avian influenza titers recovered from the copper oxide containing masks were ≤0.97±0.01 log10TCID50 and from the control masks 5.03±0.54 log10TCID50. The copper oxide containing masks successfully passed Bacterial Filtration Efficacy, Differential Pressure, Latex Particle Challenge, and Resistance to Penetration by Synthetic Blood tests designed to test the filtration properties of face masks in accordance with the European EN 14683:2005 and NIOSH N95 standards. Impregnation of copper oxide into respiratory protective face masks endows them with potent anti-influenza biocidal properties without altering their physical barrier properties. The use of biocidal masks may significantly reduce the risk of hand or environmental contamination, and thereby subsequent infection, due to improper handling and disposal of the masks.
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影响因子：
4.8
作者：
Borkow, G;Gabbay, J
通讯作者：
Gabbay, J
影响因子：
6.9
作者：
Owers, KL;James, E;Bannister, GC
通讯作者：
Bannister, GC
DOI：
10.1073/pnas.88.13.5552
发表时间：
1991-07-01
影响因子：
11.1
作者：
KARLSTROM, AR;LEVINE, RL
通讯作者：
LEVINE, RL
影响因子：
4.5
作者：
Chatterjee, A;Heybrock, B;Eischen, K
通讯作者：
Eischen, K
影响因子：
4.2
作者：
Gorter, Robert W;Butorac, Mario;Cobian, Eloy Pulido
通讯作者：
Cobian, Eloy Pulido