SARS-CoV-2 vaccination elicits unconventional IgM specific responses in naïve and previously COVID-19-infected individuals.
SARS-CoV-2 vaccination elicits unconventional IgM specific responses in naïve and previously COVID-19-infected individuals.
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DOI：
10.1016/j.ebiom.2022.103888
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发表时间：
2022-03
期刊：
影响因子：
11.1
通讯作者：
Zipeto D
中科院分区：
文献类型：
--
作者：
Ruggiero A;Piubelli C;Calciano L;Accordini S;Valenti MT;Carbonare LD;Siracusano G;Temperton N;Tiberti N;Longoni SS;Pizzato M;Accordini S;A.M.S.L.V. group;Fantoni T;Lopalco L;Beretta A;Bisoffi Z;Zipeto D
目前，全世界都在评估疫苗接种后针对 SARS-CoV-2 Spike 蛋白的 IgG 抗体来评估疫苗反应。关于疫苗引发的 IgM 抗体及其对 SARS-CoV-2 免疫的潜在影响的数据有限。我们进行了一项纵向研究，以量化接受 BNT162b2 疫苗的医护人员 (HCW) 接种者的抗 S SARS-CoV-2 IgG 和 IgM（IgG-S 和 IgM-S）。在给药前（T0）、第二次给药时（T1）和T1后三周（T2）收集样品。该队列包括 1584 名未曾感染 SARS-CoV-2 (IN) 的患者和 289 名有既往感染史 (PI) 的患者。 IN 显示三种反应模式：(a) IgG 阳性/IgM 阴性 (36.1%)，(b) T1 时出现协调的 IgM-S/IgG-S 反应 (37.4%) 和 (c) IgM 在 IgG 之后出现 (26.3%)。协调的 IgM-S/IgG-S 反应与较高的 IgG 滴度相关。在 IgM-S 阳性 PI 中，64.5% 的人在接种疫苗前呈 IgM-S 阳性，而分别有 32% 和 3.5% 在第一剂和第二剂疫苗接种后出现 IgM-S 阳性。与 IgM-S 阴性血清相比，IgM-S 阳性血清具有更高的假病毒中和滴度。疫苗接种后 IgG-S 和 IgM-S 的协调表达与抗体水平和病毒中和活性显着更有效的反应相关。非常规的 IgG-S 阳性/IgM-S 阴性反应可能表明通过疫苗接种可增强交叉冠状病毒免疫力，值得进一步研究。意大利卫生部根据“Fondi Ricerca Corrente”- L1P5 和“Progetto Ricerca Finalizzata COVID-2020-12371675”； FUR 2020 卓越部 2018-2022，MIUR，意大利；维罗纳大脑研究基金会。
Currently, evaluation of the IgG antibodies specific for the SARS-CoV-2 Spike protein following vaccination is used worldwide to estimate vaccine response. Limited data are available on vaccine-elicited IgM antibodies and their potential implication in immunity to SARS-CoV-2. We performed a longitudinal study to quantify anti-S SARS-CoV-2 IgG and IgM (IgG-S and IgM-S) in health care worker (HCW) recipients of the BNT162b2 vaccine. Samples were collected before administration (T0), at the second dose (T1) and three weeks after T1 (T2). The cohort included 1584 immunologically naïve to SARS-CoV-2 (IN) and 289 with history of previous infection (PI). IN showed three patterns of responses: (a) IgG positive/IgM negative (36.1%), (b) coordinated IgM-S/IgG-S responses appearing at T1 (37.4%) and (c) IgM appearing after IgG (26.3%). Coordinated IgM-S/IgG-S responses were associated with higher IgG titres. In IgM-S positive PI, 64.5% were IgM-S positive before vaccination, whereas 32% and 3.5% developed IgM-S after the first and second vaccine dose, respectively. IgM-S positive sera had higher pseudovirus neutralization titres compared to the IgM-S negative. Coordinated expression of IgG-S and IgM-S after vaccination was associated with a significantly more efficient response in both antibody levels and virus-neutralizing activity. The unconventional IgG-S positive/IgM-S negative responses may suggest a recruitment of cross coronaviruses immunity by vaccination, warranting further investigation. Italian Ministry of Health under “Fondi Ricerca Corrente”- L1P5 and “Progetto Ricerca Finalizzata COVID-2020-12371675”; FUR 2020 Department of Excellence 2018-2022, MIUR, Italy; The Brain Research Foundation Verona.
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影响因子：
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