The stability of silver nanoparticles in a model of pulmonary surfactant.
The stability of silver nanoparticles in a model of pulmonary surfactant.
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DOI：
10.1021/es403377p
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发表时间：
2013-10-01
影响因子：
11.4
通讯作者：
Ryan, Mary P.
中科院分区：
文献类型：
--
作者：
Leo, Bey Fen;Chen, Shu;Kyo, Yoshihiko;Herpoldt, Karla-Luise;Terrill, Nicholas J.;Dunlop, Iain E.;McPhail, David S.;Shaffer, Milo S.;Schwander, Stephan;Gow, Andrew;Zhang, Junfeng;Chung, Kian Fan;Tetley, Teresa D.;Porter, Alexandra E.;Ryan, Mary P.
银纳米颗粒（AgNP）在消费品中的日益增长的使用引起了人们对其对环境和人类健康的潜在影响的担忧。AgNP是否溶解并释放Ag+离子，或粗化以形成大的聚集体，在确定其潜在毒性方面至关重要。在这项工作中，银纳米粒子在二棕榈酰磷脂酰胆碱（DPPC），肺表面活性物质的主要成分，作为pH值的函数的稳定性进行了研究。球形，柠檬酸盐封端的银纳米粒子的平均直径为14 ± 1.6 nm（n=200）的化学浴还原制备。Ag+离子释放的动力学是强烈的pH依赖性。在高氯酸钠（NaClO 4）或高氯酸（HClO 4）溶液中孵育14天后，溶解的AgNP的总分数从pH 3的约10%变化到pH 5的约2%，pH 7的溶解可忽略不计。pH从7降低到3也促进了颗粒聚集和粗化。DPPC（100 mg.L-1）延迟了Ag+离子的释放，但两周后并未显着改变Ag+释放总量。此外，DPPC改善了AgNPs的分散性，抑制了聚集和粗化。TEM图像显示AgNP被用作半渗透层的DPPC层包覆。因此，肺衬里液，特别是DPPC，可以改变肺中吸入的AgNP的Ag+离子释放的聚集状态和动力学。这些观察结果对于预测AgNPs在肺和环境中的潜在反应性具有重要意义。
The growing use of silver nanoparticles (AgNPs) in consumer products has raised concerns about their potential impact on the environment and human health. Whether AgNPs dissolve and release Ag+ ions, or coarsen to form large aggregates, is critical in determining their potential toxicity. In this work, the stability of AgNPs in dipalmitoylphosphatidylcholine (DPPC), the major component of pulmonary surfactant, was investigated as a function of pH. Spherical, citrate-capped AgNPs with average diameters of 14 ± 1.6 nm (n=200) were prepared by a chemical bath reduction. The kinetics of Ag+ ion release was strongly pH-dependent. After 14 days of incubation in sodium perchlorate (NaClO4) or perchloric acid (HClO4) solutions, the total fraction of AgNPs dissolved varied from ~10 % at pH 3, to ~2 % at pH 5, with negligible dissolution at pH 7. A decrease in pH from 7 to 3 also promoted particle aggregation and coarsening. DPPC (100 mg.L−1) delayed the release of Ag+ ions, but did not significantly alter the total amount of Ag+ released after two weeks. In addition, DPPC improved the dispersion of the AgNPs and inhibited aggregation and coarsening. TEM images revealed that the AgNPs were coated with a DPPC layer serving as a semi-permeable layer. Hence, lung lining fluid, particularly DPPC, can modify the aggregation state and kinetics of Ag+ ion release of inhaled AgNPs in the lung. These observations have important implications for predicting the potential reactivity of AgNPs in the lung and the environment.
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影响因子：
4.1
作者：
Bae, Eunjoo;Park, Hee-Jin;Yi, Jongheop
通讯作者：
Yi, Jongheop
影响因子：
3.3
作者：
GOERKE, J;GONZALES, J
通讯作者：
GONZALES, J
影响因子：
3.7
作者：
Guzman, Eduardo;Liggieri, Libero;Ravera, Francesca
通讯作者：
Ravera, Francesca
影响因子：
11.4
作者：
El Badawy, Amro M.;Silva, Rendahandi G.;Tolaymat, Thabet M.
通讯作者：
Tolaymat, Thabet M.
DOI：
10.1007/s00339-008-4434-1
发表时间：
2008-06-01
影响因子：
2.7
作者：
Damm, C.;Munstedt, H.
通讯作者：
Munstedt, H.