Influence of Antibiotic-Loaded Acrylic Bone Cement Composition on Drug Release Behavior and Mechanism.
Influence of Antibiotic-Loaded Acrylic Bone Cement Composition on Drug Release Behavior and Mechanism.
复制标题
DOI：
10.3390/polym13142240
复制
发表时间：
2021-07-08
期刊：
影响因子：
5
通讯作者：
Fang HW
中科院分区：
文献类型：
--
作者：
Chen IC;Su CY;Nien WH;Huang TT;Huang CH;Lu YC;Chen YJ;Huang GC;Fang HW
人工关节周围感染（PJI）是全关节置换术后的一种严重并发症，具有相当高的发病率和巨大的经济负担。抗生素骨水泥（ALBC）已被开发为一种有价值的局部给药工具，并正在成为预防和治疗骨科感染的最有效方法之一。控制抗生素从ALBC中的释放对于实现有效的感染控制至关重要，然而，抗生素洗脱率通常较低，并且机制知之甚少。因此，本研究旨在研究基本丙烯酸骨水泥组分，包括液体/粉末（单体与聚合物）比、不透射线剂、引发剂和抗生素剂量对聚甲基丙烯酸甲酯（PMMA）基ALBC的孔隙率、抗生素洗脱速率和机械性能的影响。体外研究结果表明，液粉比的降低、不透射线剂比和庆大霉素剂量的增加会导致孔隙率和抗生素释放增加，而引发剂比对洗脱率没有影响。总之，我们希望通过改变ALBC的组成，我们可以通过增加孔隙率来显著提高抗生素洗脱率，同时保持骨水泥的足够机械强度。这一发现可能为控制ALBC的抗生素释放提供见解，以实现全关节置换术后有效的感染控制。
Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement with considerable morbidity and large economic burdens. Antibiotic-Loaded Bone Cement (ALBC) has been developed as a valuable tool for local administration and is becoming one of the most effective methods for the prevention and treatment of orthopedic infections. Controlling antibiotic release from ALBC is critical to achieve effective infection control, however, the antibiotic elution rates are generally low, and the mechanisms are poorly understood. Thus, the present study aims to investigate the effects of the basic acrylic bone cement components, including liquid/powder (monomer-to-polymer) ratios, radiopacifier, initiator, and doses of antibiotics on the porosity, antibiotic elution rates and mechanical properties of polymethylmethacrylate (PMMA) based ALBC. The obtained results from the in vitro studies suggested that a reduction in the liquid/powder ratio and an increase in the radiopacifier ratio and gentamicin doses led to increased porosity and release of antibiotic, while the initiator ratio exerted no effect on elution rates. In conclusion, we hope that by varying the composition of ALBC, we could considerably enhance the antibiotic elution rates by increasing porosity, while maintaining an adequate mechanical strength of the bone cements. This finding might provide insights into controlling antibiotic release from ALBC to achieve effective infection control after total joint replacement surgery.
登录
查看更多内容
DOI：
10.5402/2011/290851
发表时间：
2011
期刊：
ISRN orthopedics
影响因子：
--
作者：
Bistolfi A;Massazza G;Verné E;Massè A;Deledda D;Ferraris S;Miola M;Galetto F;Crova M
通讯作者：
Crova M
影响因子：
3.7
作者：
Lee SH;Tai CL;Chen SY;Chang CH;Chang YH;Hsieh PH
通讯作者：
Hsieh PH
DOI：
10.1243/09544119jeim355
发表时间：
2008-04-01
影响因子：
1.8
作者：
Dunne, N. I.;Hill, I.;Tunney, M.
通讯作者：
Tunney, M.
影响因子：
4.7
作者：
Perni, Stefano;Caserta, Sergio;Prokopovich, Polina
通讯作者：
Prokopovich, Polina
影响因子：
2.3
作者：
Liawrungrueang W;Ungphaiboon S;Jitsurong A;Ingviya N;Tangtrakulwanich B;Yuenyongviwat V
通讯作者：
Yuenyongviwat V