Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.
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鼠类寿命对饮食限制的反应中的遗传变异：从寿命延长到寿命缩短。
DOI：
10.1111/j.1474-9726.2009.00533.x
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发表时间：
2010-02
期刊：
影响因子：
7.8
通讯作者：
Nelson JF
中科院分区：
文献类型：
--
作者：
Liao CY;Rikke BA;Johnson TE;Diaz V;Nelson JF
慢性饮食限制（DR）被认为是最强大的延长寿命的干预措施之一，但一些报告表明，DR并不总是延长，甚至可能缩短某些基因型的寿命。一直缺乏一个公正的遗传筛查的寿命响应DR。在这里，我们测量了一种常用的饮食限制水平（DR：减少40%的食物摄入量）对41个重组近交系（RI）小鼠的处女雄性和雌性的平均寿命的影响。雄性和雌性动物的平均菌株特异性寿命分别在自由采食（AL）下变化2- 3倍，在DR下变化6- 10倍。值得注意的是，DR缩短寿命的菌株比延长寿命的菌株多。食物摄入量和女性生育能力显着不同的菌株下AL喂养，但既不预测DR生存：因此，菌株中DR缩短寿命没有低食物摄入量或不良的生殖潜力。最后，DR和AL喂养下的菌株特异性寿命不相关，表明这两种条件下寿命的遗传决定因素不同。这些结果表明，寿命响应于一个单一的DR水平表现出广泛的变化，适合遗传分析。他们还表明，DR可以缩短近交系小鼠的寿命。虽然在40%DR下寿命缩短的菌株在不太严格的DR下可能不会产生负面反应，但结果表明DR延长寿命可能不具有普遍性。
Chronic dietary restriction (DR) is considered among the most robust life-extending interventions, but several reports indicate that DR does not always extend and may even shorten lifespan in some genotypes. An unbiased genetic screen of the lifespan response to DR has been lacking. Here we measured the effect of one commonly used level of dietary restriction (DR: 40% reduction in food intake) on mean lifespan of virgin males and females in 41 recombinant inbred (RI) strains of mice. Mean strain-specific lifespan varied 2- to 3-fold under ad libitum (AL) feeding and 6- to 10-fold under DR, in males and females, respectively. Notably, DR shortened lifespan in more strains than those in which it lengthened life. Food intake and female fertility varied markedly among strains under AL feeding, but neither predicted DR survival: therefore, strains in which DR shortened lifespan did not have low food intake or poor reproductive potential. Finally, strain-specific lifespans under DR and AL feeding were not correlated, indicating that the genetic determinants of lifespan under these two conditions differ. These results demonstrate that the lifespan response to a single level of DR exhibits wide variation amenable to genetic analysis. They also show that DR can shorten lifespan in inbred mice. Although strains with shortened lifespan under 40% DR may not respond negatively under less stringent DR, the results raise the possibility that life extension by DR may not be universal.
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影响因子：
7.8
作者：
Fontana L;Weiss EP;Villareal DT;Klein S;Holloszy JO
通讯作者：
Holloszy JO
影响因子：
7.8
作者：
Harper, James M.;Leathers, Charles W.;Austad, Steven N.
通讯作者：
Austad, Steven N.
DOI：
10.1093/gerona/62.10.1059
发表时间：
2007-10-01
影响因子：
5.1
作者：
McCarter, Roger;Mejia, Walter;Strong, Randy
通讯作者：
Strong, Randy
DOI：
10.1093/gerona/54.11.b492
发表时间：
1999-11-01
影响因子：
5.1
作者：
Turturro, A;Witt, WW;Hart, RW
通讯作者：
Hart, RW
影响因子：
4.8
作者：
Forster, MJ;Morris, P;Sohal, RS
通讯作者：
Sohal, RS