Altered intrahemispheric structural connectivity in Gilles de la Tourette syndrome.
Altered intrahemispheric structural connectivity in Gilles de la Tourette syndrome.
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DOI：
10.1016/j.nicl.2013.11.011
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发表时间：
2014
影响因子：
4.2
通讯作者：
Thomalla, Goetz
中科院分区：
文献类型：
--
作者：
Cheng, Bastian;Braass, Hanna;Ganos, Christos;Treszl, Andras;Biermann-Ruben, Katja;Hummel, Friedhelm C.;Mueller-Vahl, Kirsten;Schnitzler, Alfons;Gerloff, Christian;Muenchau, Alexander;Thomalla, Goetz
抽动秽语综合征（GTS）是一种常见的发育性神经精神障碍，其特征是抽搐和频繁的精神共病，通常导致严重残疾。抽搐的产生与参与计划、控制和执行动作的大脑区域的紊乱网络有关，特别是纹状体和皮质-纹状体-丘脑-皮质回路中的结构和功能障碍。因此，我们应用结构扩散张量成像（DTI）来表征15例无精神病合并症的GTS患者中参与运动控制的皮质-皮质下回路中半球内白色物质连通性的变化。白色物质的连通性进行了分析的概率纤维束成像之间的12个预定义的皮质和皮质下区域的利益。连接值与耶鲁整体抽动严重程度量表（YGTSS）评定的临床严重程度相结合。GTS患者表现出广泛的结构连接缺陷。较低的连接值被发现，特别是在连接补充运动区（SMA）与基底神经节（前SMA-壳核，SMA-壳核）和额叶皮质-皮质电路的束。有一个整体的趋势，在这些大片和YGTSS分数的结构连接之间的负相关。在成年GTS患者中，参与计划、控制和执行动作的额叶脑网络的结构连接性降低，这与抽搐的严重程度相关。这些发现符合GTS作为大脑不成熟的神经发育障碍的概念。我们用扩散张量成像检查了抽动秽语综合征的白色物质通路。GTS患者表现出广泛的结构连接缺陷。GTS患者的连通性改变与抽动严重程度相关。我们的研究结果符合GTS作为大脑不成熟障碍的概念。
Gilles de la Tourette syndrome (GTS) is a common developmental neuropsychiatric disorder characterized by tics and frequent psychiatric comorbidities, often causing significant disability. Tic generation has been linked to disturbed networks of brain areas involved in planning, controlling and execution of actions, particularly structural and functional disorders in the striatum and cortico–striato–thalamo–cortical loops. We therefore applied structural diffusion tensor imaging (DTI) to characterize changes in intrahemispheric white matter connectivity in cortico-subcortical circuits engaged in motor control in 15 GTS patients without psychiatric comorbidities. White matter connectivity was analyzed by probabilistic fiber tractography between 12 predefined cortical and subcortical regions of interest. Connectivity values were combined with measures of clinical severity rated by the Yale Global Tic Severity Scale (YGTSS). GTS patients showed widespread structural connectivity deficits. Lower connectivity values were found specifically in tracts connecting the supplementary motor areas (SMA) with basal ganglia (pre-SMA–putamen, SMA–putamen) and in frontal cortico-cortical circuits. There was an overall trend towards negative correlations between structural connectivity in these tracts and YGTSS scores. Structural connectivity of frontal brain networks involved in planning, controlling and executing actions is reduced in adult GTS patients which is associated with tic severity. These findings are in line with the concept of GTS as a neurodevelopmental disorder of brain immaturity. We examine white matter pathways in Tourette syndrome with diffusion tensor imaging. GTS patients showed widespread structural connectivity deficits. Altered connectivity in GTS patients was associated with tic severity. Our findings are in line with the concept of GTS as disorder of brain immaturity.
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DOI：
10.1093/brain/awq300
发表时间：
2010-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Draganski B;Martino D;Cavanna AE;Hutton C;Orth M;Robertson MM;Critchley HD;Frackowiak RS
通讯作者：
Frackowiak RS
影响因子：
14.5
作者：
Berlin, HA;Rolls, ET;Kischka, U
通讯作者：
Kischka, U
DOI：
10.1073/pnas.0403743101
发表时间：
2004-09-07
影响因子：
11.1
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
通讯作者：
Matthews, PM
影响因子：
14.5
作者：
Church, Jessica A.;Fair, Damien A.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Miezin, Francis M.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.
影响因子：
4.8
作者：
Govindan, Rajkumar Munian;Makki, Malek I.;Chugani, Harry T.
通讯作者：
Chugani, Harry T.