Friend virus severity is associated with male mouse social status and environmental temperature.
Friend virus severity is associated with male mouse social status and environmental temperature.
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DOI：
10.1016/j.anbehav.2022.03.009
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发表时间：
2022-05
期刊：
影响因子：
2.5
通讯作者：
Potts, Wayne K.
中科院分区：
文献类型：
--
作者：
Stark, Derek L.;Cauceglia, Joseph W.;Sitzman, Victoria N.;Repetto, Mayra C.;Tadje, Jacob M.;Potts, Wayne K.
关键词：
病原体的毒力在种群内是高度可变的，尽管已知许多导致毒力差异的因素，但仍有许多变异无法解释。因此，识别和表征与不同毒力水平相关的环境条件是传染病研究中的一项重要任务。社会地位被认为是社会动物整体健康和疾病易感性的主要决定因素之一。与社会地位相关的健康差异被认为是由地位较高和地位较低的个体的不同程度的慢性压力造成的。有相当多的证据表明，这些影响延伸到常设免疫概况，社会地位直接影响对病原体的易感性。在这里，我们研究了雄性野生家鼠，小家鼠的优势地位之间的关联，并在激烈的雄性-雄性竞争和无捕食的自然种群的背景下，朋友病毒复合体的易感性。由于我们设施的供暖系统中断，我们意外地获得了评估环境温度降低如何影响宿主社会地位和病原体毒力的机会。环境温度被认为是病原体毒力的一个贡献者，这给了我们一个独特的机会来研究它在以前未经研究的病原体系统中的作用，而社会地位的增加可以扩大我们对不同环境条件的相互作用如何影响毒力的理解。我们发现，病原体的毒力和复制较低的社会优势主机相比，非优势主机。当温度降低时，凉爽的密闭室中的优势男性比温暖的密闭室中的男性更容易感染。将传染病和社会地位联系起来的机制基础仍然难以从其相关因素中解脱出来，但这项研究为未来在现有研究最充分的哺乳动物模型中使用新方法进行实验打开了大门。
Pathogen virulence is highly variable within populations, and although many factors contributing to virulence differences are known, there is still much variation left unexplained. Identifying and characterizing environmental conditions associated with different virulence levels is therefore an important undertaking in infectious disease research. One factor considered to be a major determinant of overall health and susceptibility to disease in social animals is social status. Health differences associated with social status are thought to be caused by different levels of chronic stress in higher- versus lower-status individuals. There is considerable evidence that these effects extend to the standing immune profile and that social status directly influences susceptibility to pathogens. Here we examined the association between dominance status in male wild-derived house mice, Mus musculus, and susceptibility to Friend virus complex in the context of seminatural populations with intense male–male competition and no predation. Due to an interruption in our facility’s heating system, we were unexpectedly presented with the opportunity to assess how reduced ambient temperature influences the association of host social status and pathogen virulence. Environmental temperature has been implicated as a contributor to pathogen virulence, giving us a unique chance to examine its role in a previously unexamined pathogen system, while the added context of social status can expand our understanding of how the interaction of different environmental conditions affects virulence. We found that pathogen virulence and replication were lower in socially dominant hosts compared to nondominant hosts. When temperature was reduced, cool enclosure-housed dominant males were more susceptible to infection than their warm enclosure-housed counterparts. The mechanistic underpinnings that link infectious disease and social status remain difficult to disentangle from their associated factors, but this study opens the door for future experiments using a novel approach in the most well-studied mammalian model available.
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