Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes.
Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes.
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比较宏基因组学揭示了人肠道微生物组中通常富集的基因集。
DOI：
10.1093/dnares/dsm018
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发表时间：
2007-08-31
期刊：
影响因子：
4.1
通讯作者：
Hattori, Masahira
中科院分区：
文献类型：
--
作者：
Kurokawa, Ken;Itoh, Takehiko;Kuwahara, Tomomi;Oshima, Kenshiro;Toh, Hidehiro;Toyoda, Atsushi;Takami, Hideto;Morita, Hidetoshi;Sharma, Vineet K.;Srivastava, Tulika P.;Taylor, Todd D.;Noguchi, Hideki;Mori, Hiroshi;Ogura, Yoshitoshi;Ehrlich, Dusko S.;Itoh, Kikuji;Takagi, Toshihisa;Sakaki, Yoshiyuki;Hayashi, Tetsuya;Hattori, Masahira
许多微生物居住在人类的肠道中，其中许多是无法培养的或无法培养的。 - 来自13个健康年龄段的粪便样品（包括不明显的婴儿）的元基因组分析。不明智的婴儿很简单，并且在分类学和基因组成方面表现出很高的个体差异，成人和断奶儿童的人更为复杂，但无论年龄或性别如何，都表现出较高的功能均匀性。 ，我们确定了237个基因家族，通常以成年人类型富集，而婴儿型微生物组中有136个家族，对它们的预测功能进行了较小的重叠。每种类型的菌群都采用的各种策略适应其肠道环境，表明这些基因集编码成人和婴儿型肠道菌群的核心功能，通过分析孤儿基因。人类肠道微生物组。微生物之间水平基因转移的“热点”。
Numerous microbes inhabit the human intestine, many of which are uncharacterized or uncultivable. They form a complex microbial community that deeply affects human physiology. To identify the genomic features common to all human gut microbiomes as well as those variable among them, we performed a large-scale comparative metagenomic analysis of fecal samples from 13 healthy individuals of various ages, including unweaned infants. We found that, while the gut microbiota from unweaned infants were simple and showed a high inter-individual variation in taxonomic and gene composition, those from adults and weaned children were more complex but showed a high functional uniformity regardless of age or sex. In searching for the genes over-represented in gut microbiomes, we identified 237 gene families commonly enriched in adult-type and 136 families in infant-type microbiomes, with a small overlap. An analysis of their predicted functions revealed various strategies employed by each type of microbiota to adapt to its intestinal environment, suggesting that these gene sets encode the core functions of adult and infant-type gut microbiota. By analysing the orphan genes, 647 new gene families were identified to be exclusively present in human intestinal microbiomes. In addition, we discovered a conjugative transposon family explosively amplified in human gut microbiomes, which strongly suggests that the intestine is a ‘hot spot’ for horizontal gene transfer between microbes.
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Pfam：氏族、网络工具和服务。
影响因子：
14.9
作者：
Finn, Robert D.;Mistry, Jaina;Schuster-Bockler, Benjamin;Griffiths-Jones, Sam;Hollich, Volker;Lassmann, Timo;Moxon, Simon;Marshall, Mhairi;Khanna, Ajay;Durbin, Richard;Eddy, Sean R.;Sonnhammer, Erik L. L.;Bateman, Alex
通讯作者：
Bateman, Alex
影响因子：
14.9
作者：
Kunin V;Ahren D;Goldovsky L;Janssen P;Ouzounis CA
通讯作者：
Ouzounis CA
影响因子：
56.9
作者：
Bry, L;Falk, PG;Gordon, JI
通讯作者：
Gordon, JI
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
4.4
作者：
Favier, CF;Vaughan, EE;Akkermans, ADL
通讯作者：
Akkermans, ADL