A Functional Genetic Variant at the C-Reactive Protein Promoter (rs3091244) Is Not Associated With Cancer Risk in a Chinese Population
A Functional Genetic Variant at the C-Reactive Protein Promoter (rs3091244) Is Not Associated With Cancer Risk in a Chinese Population
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C反应蛋白启动子（rs3091244）的功能性遗传变异与中国人群的癌症风险无关
DOI：
10.3389/fimmu.2020.00926
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发表时间：
2020-05
影响因子：
7.3
通讯作者：
Yi Wu
中科院分区：
文献类型：
--
作者：
Ming-Yu Wang;Hai-Hong Zhou;Chun-Miao Zhang;Hai-Xiang Su;Shuo-Lei Li;Shang-Rong Ji;Enqi Liu;Yi Wu
背景：在欧洲人群中，循环C反应蛋白（CRP）基因水平升高与癌症风险的关联已被广泛研究；然而，结论存在矛盾。三等位基因rs3091244是一种……（原文“funct”似乎不完整）
Background: The association of genetically elevated levels of circulating C-reactive protein (CRP) with cancer risk has been extensively investigated in European populations; however, there are conflicting conclusions. The tri-allelic rs3091244 is a functionally validated genetic variant, and its allelic frequencies differ significantly between European and Asian populations. Here, we examined the association of rs3091244 with cancer risk in a Chinese population. Methods: rs3091244 was genotyped by Sanger sequencing in 4,971 cancer cases and 2,485 controls. The rs1205 and rs2794521 gene variants were also genotyped using TaqMan assays in subgroups. Results: No association was detected between the genotyped CRP variants and cancer risk, with or without distinguishing cancer types, suggesting that circulating CRP is not causally involved in tumorigenesis in Chinese populations.
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影响因子：
6.4
作者：
Slattery, Martha L.;Curtin, Karen;Poole, Elizabeth M.;Duggan, David J.;Samowitz, Wade S.;Peters, Ulrike;Caan, Bette J.;Potter, John D.;Ulrich, Cornelia M.
通讯作者：
Ulrich, Cornelia M.
C反应性蛋白质和前列腺癌风险之间的遗传变异。
影响因子：
2.8
作者：
Markt, Sarah C.;Rider, Jennifer R.;Penney, Kathryn L.;Schumacher, Fredrick R.;Epstein, Mara M.;Fall, Katja;Sesso, Howard D.;Stampfer, Meir J.;Mucci, Lorelei A.
通讯作者：
Mucci, Lorelei A.
DOI：
10.1126/science.341.6148.821-c
发表时间：
2016-03
期刊：
Im OP
影响因子：
--
作者：
Birgit Kasch
通讯作者：
Birgit Kasch
DOI：
10.1155/2013/379040
发表时间：
2013-09-14
期刊：
ISRN inflammation
影响因子：
--
作者：
Du Clos TW
通讯作者：
Du Clos TW
影响因子：
50.3
作者：
Yang, Jing;Wezeman, Michele;Yi, Qing
通讯作者：
Yi, Qing