Trans-acting small interfering RNA4: key to nutraceutical synthesis in grape development?

Trans-acting small interfering RNA4: key to nutraceutical synthesis in grape development?
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DOI:
10.1016/j.tplants.2013.07.006
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发表时间:
2013-11
影响因子:
20.5
通讯作者:
Rock, Christopher D.
Rock, Christopher D.
中科院分区:
生物学1区
文献类型:
--
作者:
Rock, Christopher D.

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MicroRNAs(MiRNAs)进化和改变的方便性和多功能性可能是它们如何成为真核生物基因组的主导成分的基础。在这篇评论文章中,我提出反式作用小干扰RNA基因4(TAS4)的进化可能对多酚类物质的生物合成、丛枝共生和细菌病原体的致病起重要作用。基于表达和系统发育的证据表明,TAS4针对两个新的葡萄(Vitis vinifera L.)MYB转录因子(VvMYBA6,VvMYBA7)产生阶段性siRNAs,可能在营养食品生物类黄酮的生物合成和果实发育中发挥作用。表征TAS4控制植物发育和整合到生物和非生物胁迫和营养信号调控网络的分子机制对于分子育种和开发设计更健康食品的策略具有适用性。
The facility and versatility of microRNAs (miRNAs) to evolve and change likely underlies how they have become dominant constituents of eukaryotic genomes. In this opinion article I propose that trans-acting small interfering RNA gene 4 (TAS4) evolution may be important for biosynthesis of polyphenolics, arbuscular symbiosis, and bacterial pathogen etiologies. Expression-based and phylogenetic evidence shows that TAS4 targets two novel grape (Vitis vinifera L.) MYB transcription factors (VvMYBA6, VvMYBA7) that spawn phased siRNAs and likely function in nutraceutical bioflavonoid biosynthesis and fruit development. Characterization of the molecular mechanisms of TAS4 control of plant development and integration into biotic and abiotic stress- and nutrient signaling regulatory networks has applicability to molecular breeding and development of strategies for engineering healthier foods.
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